Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

Selmir Avdic, Brian P. McSharry, Barry Slobedman

Research output: Contribution to journalShort surveypeer-review

22 Citations (Scopus)

Abstract

Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.

Original languageEnglish
Article number337
Pages (from-to)1-5
Number of pages5
JournalFrontiers in Microbiology
Volume5
DOIs
Publication statusPublished - 2014

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