Molecular signatures of beef tenderness: Underlying mechanisms based on integromics of protein biomarkers from multi-platform proteomics studies

Mohammed Gagaoua, E M Claudia Terlouw, Anne Maria Mullen, Daniel Franco, Robyn D. Warner, José M Lorenzo, Peter P Purslow, David Gerrard, David L Hopkins, Declan Troy, Brigitte Picard

    Research output: Contribution to journalReview articlepeer-review

    47 Citations (Scopus)

    Abstract

    Over the last two decades, proteomics have been employed to decipher the underlying factors contributing to variation in the quality of muscle foods, including beef tenderness. One such approach is the application of high-throughput protein analytical platforms in the identification of meat quality biomarkers. To broaden our understanding about the biological mechanisms underpinning meat tenderization across a large number of studies, an integromics study was performed to review the current status of protein biomarker discovery targeting beef tenderness. This meta-analysis is the first to gather and propose a comprehensive list of 124 putative protein biomarkers derived from 28 independent proteomics-based experiments, from which 33 robust candidates were identified worthy of evaluation using targeted or untargeted data-independent acquisition proteomic methods. We further provide an overview of the interconnectedness of the main biological pathways impacting tenderness determination after multistep analyses including Gene Ontology annotations, pathway and process enrichment and literature mining, and specifically discuss the major proteins and pathways most often reported in proteomics research.

    Original languageEnglish
    Article number108311
    Pages (from-to)1-27
    Number of pages27
    JournalMeat Science
    Volume172
    Early online date19 Sep 2020
    DOIs
    Publication statusPublished - Feb 2021

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