Molecularly imprinted polymer membranes and thin films for the separation and sensing of biomacromolecules

Reinhard I. Boysen, Lachlan J. Schwarz, Dan V. Nicolau, Milton T. W. Hearn

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

This review describes recent advances associated with the development of surface imprinting methods for the synthesis of polymeric membranes and thin films, which possess the capability to selectively and specifically recognize biomacromolecules, such as proteins and single- and double-stranded DNA, employing “epitope” or “whole molecule” approaches. Synthetic procedures to create different molecularly imprinted polymer membranes or thin films are discussed, including grafting/in situ polymerization, drop-, dip-, or spin-coating procedures, electropolymerization as well as micro-contact or stamp lithography imprinting methods. Highly sensitive techniques for surface characterization and analyte detection are described, encompassing luminescence and fluorescence spectroscopy, X-ray photoelectron spectroscopy, FTIR spectroscopy, surface-enhanced Raman spectroscopy, atomic force microscopy, quartz crystal microbalance analysis, cyclic voltammetry, and surface plasmon resonance. These developments are providing new avenues to produce bioelectronic sensors and new ways to explore through advanced separation science procedures complex phenomena associated with the origins of biorecognition in nature.
Original languageEnglish
Pages (from-to)314-335
Number of pages22
JournalJournal of Separation Science
Volume40
Issue number1
Early online dateOct 2016
DOIs
Publication statusPublished - 01 Jan 2017

Fingerprint

Polymers
Membranes
Thin films
Epitopes
Polymeric membranes
Electropolymerization
Quartz crystal microbalances
Single-Stranded DNA
Fluorescence spectroscopy
Spin coating
Surface plasmon resonance
Lithography
Cyclic voltammetry
Raman spectroscopy
Luminescence
Atomic force microscopy
DNA
X ray photoelectron spectroscopy
Polymerization
Spectroscopy

Cite this

Boysen, Reinhard I. ; Schwarz, Lachlan J. ; Nicolau, Dan V. ; Hearn, Milton T. W. / Molecularly imprinted polymer membranes and thin films for the separation and sensing of biomacromolecules. In: Journal of Separation Science. 2017 ; Vol. 40, No. 1. pp. 314-335.
@article{e3b2d42f4a804fcdae0d5bd2b32f3f9b,
title = "Molecularly imprinted polymer membranes and thin films for the separation and sensing of biomacromolecules",
abstract = "This review describes recent advances associated with the development of surface imprinting methods for the synthesis of polymeric membranes and thin films, which possess the capability to selectively and specifically recognize biomacromolecules, such as proteins and single- and double-stranded DNA, employing “epitope” or “whole molecule” approaches. Synthetic procedures to create different molecularly imprinted polymer membranes or thin films are discussed, including grafting/in situ polymerization, drop-, dip-, or spin-coating procedures, electropolymerization as well as micro-contact or stamp lithography imprinting methods. Highly sensitive techniques for surface characterization and analyte detection are described, encompassing luminescence and fluorescence spectroscopy, X-ray photoelectron spectroscopy, FTIR spectroscopy, surface-enhanced Raman spectroscopy, atomic force microscopy, quartz crystal microbalance analysis, cyclic voltammetry, and surface plasmon resonance. These developments are providing new avenues to produce bioelectronic sensors and new ways to explore through advanced separation science procedures complex phenomena associated with the origins of biorecognition in nature.",
keywords = "Biomacromolecules, Membranes, Molecularly imprinted polymers, Surface imprinting, Thin films",
author = "Boysen, {Reinhard I.} and Schwarz, {Lachlan J.} and Nicolau, {Dan V.} and Hearn, {Milton T. W.}",
note = "Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Journal of Separation Science. ISSNs: 1615-9314;",
year = "2017",
month = "1",
day = "1",
doi = "10.1002/jssc.201600849",
language = "English",
volume = "40",
pages = "314--335",
journal = "HRC Journal of High Resolution Chromatography",
issn = "1615-9306",
publisher = "Wiley-VCH Verlag",
number = "1",

}

Molecularly imprinted polymer membranes and thin films for the separation and sensing of biomacromolecules. / Boysen, Reinhard I.; Schwarz, Lachlan J.; Nicolau, Dan V.; Hearn, Milton T. W.

In: Journal of Separation Science, Vol. 40, No. 1, 01.01.2017, p. 314-335.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Molecularly imprinted polymer membranes and thin films for the separation and sensing of biomacromolecules

AU - Boysen, Reinhard I.

AU - Schwarz, Lachlan J.

AU - Nicolau, Dan V.

AU - Hearn, Milton T. W.

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Journal of Separation Science. ISSNs: 1615-9314;

PY - 2017/1/1

Y1 - 2017/1/1

N2 - This review describes recent advances associated with the development of surface imprinting methods for the synthesis of polymeric membranes and thin films, which possess the capability to selectively and specifically recognize biomacromolecules, such as proteins and single- and double-stranded DNA, employing “epitope” or “whole molecule” approaches. Synthetic procedures to create different molecularly imprinted polymer membranes or thin films are discussed, including grafting/in situ polymerization, drop-, dip-, or spin-coating procedures, electropolymerization as well as micro-contact or stamp lithography imprinting methods. Highly sensitive techniques for surface characterization and analyte detection are described, encompassing luminescence and fluorescence spectroscopy, X-ray photoelectron spectroscopy, FTIR spectroscopy, surface-enhanced Raman spectroscopy, atomic force microscopy, quartz crystal microbalance analysis, cyclic voltammetry, and surface plasmon resonance. These developments are providing new avenues to produce bioelectronic sensors and new ways to explore through advanced separation science procedures complex phenomena associated with the origins of biorecognition in nature.

AB - This review describes recent advances associated with the development of surface imprinting methods for the synthesis of polymeric membranes and thin films, which possess the capability to selectively and specifically recognize biomacromolecules, such as proteins and single- and double-stranded DNA, employing “epitope” or “whole molecule” approaches. Synthetic procedures to create different molecularly imprinted polymer membranes or thin films are discussed, including grafting/in situ polymerization, drop-, dip-, or spin-coating procedures, electropolymerization as well as micro-contact or stamp lithography imprinting methods. Highly sensitive techniques for surface characterization and analyte detection are described, encompassing luminescence and fluorescence spectroscopy, X-ray photoelectron spectroscopy, FTIR spectroscopy, surface-enhanced Raman spectroscopy, atomic force microscopy, quartz crystal microbalance analysis, cyclic voltammetry, and surface plasmon resonance. These developments are providing new avenues to produce bioelectronic sensors and new ways to explore through advanced separation science procedures complex phenomena associated with the origins of biorecognition in nature.

KW - Biomacromolecules

KW - Membranes

KW - Molecularly imprinted polymers

KW - Surface imprinting

KW - Thin films

UR - http://www.scopus.com/inward/record.url?scp=84991698411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991698411&partnerID=8YFLogxK

U2 - 10.1002/jssc.201600849

DO - 10.1002/jssc.201600849

M3 - Review article

VL - 40

SP - 314

EP - 335

JO - HRC Journal of High Resolution Chromatography

JF - HRC Journal of High Resolution Chromatography

SN - 1615-9306

IS - 1

ER -