Mouse models of telencephalic development

P.A. Zaki, J.C. Quinn, D.J. Price

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)


    As the telencephalon first emerges from anterior neuroectoderm, signalling molecules and transcription factors combine to specify the identity and fate of cells in each of its regions. Studies of both naturally occurring and transgenic mutant mice have identified many genes that contribute to this process. The development of telencephalon and its regions is specified by signalling molecules produced at sites both surrounding and within the telencephalon. Different parts of the telencephalon express different combinations of transcription factors that control processes including proliferation, cell fate determination and migration in order to create the unique phenotype of each region.
    Original languageEnglish
    Pages (from-to)423-437
    Number of pages15
    JournalCurrent Opinion in Genetics and Development
    Issue number4
    Publication statusPublished - 2003


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