Multidimensional and comprehensive: Two-dimensional gas chromatography

Philip J Marriott, Paul D Morrison, Robert A Shellie, Michael S Dunn, Eka Sari, Danielle Ryan

Research output: Contribution to journalArticlepeer-review


Coupled-column GC analysis has had a long and successful history. From methods as diverse as simple direct sequential connection of columns, through intermediate pressure-tuning and flow-modulated operation, to conventional and advanced heartcut multidimensional GC (MDGC), and most recently comprehensive two-dimensional gas chromatography (GCxGC), it is clear that the search for innovative ways with which to exploit the ease of multi(dual)-column geometries for enhancing the separation power of GC has been an on-going goal. Here, we explore briefly the different modes that have been used in MDGC, highlighting the GCxGC technique, and the ways that these have opened up various expanded capacity strategies for volatile and complex sample analysis. The long history of MDGC belies the very recent surge in activity surrounding GCxGC, and we conclude that this offers the ultimate high-resolution opportunity for volatile and semi-volatile analysis. Within the technology specifically developed for GCxGC, several new multidimensional approaches have been developed in parallel. These are also placed into context.
Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalLC-GC Europe
Issue number12A
Publication statusPublished - 2003


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