Multiscale Cardiovascular Autonomic Modulation Following Treatment in Patients with Anorexia Nervosa

Herbert Jelinek, DJ Cornforth, SP Lam, J Russell, I Spence

Research output: Book chapter/Published conference paperConference paperpeer-review


Eating disorders such as Anorexia Nervosa may be associated with changes in the cardiovascular system. Such changes have the potential to be identified using analysis of Heart Rate Variability (HRV). This study investigates multiscale HRV analysis in order to identify possible changes in the autonomic control of the cardiovascular system in subjects with anorexia nervosa. We investigated R-R intervals recorded during sitting position at admission and following a 6-week treatment program. HRV analysis included standard deviation and higher moments of R-R interval, as well as multiscale Renyi entropy. Analysis using multiscale measures may prove a useful diagnostic and prognostic tool in anorexia nervosa, particularly in clinical monitoring of patients with increased risk of cardiovascular complications and sudden death. Results showed statistically significant differences between controls and patients before intervention, suggesting changes to the cardiovascular autonomic function associated with eating disorders, which can be observed before treatment but not after. This can be observed in 20-minute recordings but not in 5-minute recordings.
Original languageEnglish
Title of host publicationComputing in Cardiology 2014
Subtitle of host publicationVolume 41
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781479943470
ISBN (Print)9781479943463
Publication statusPublished - 2014
Event41st Computing in Cardiology Conference, CinC 2014 - MIT's Laboratory for Computational Physiology, Cambridge, United States
Duration: 07 Sep 201410 Sep 2014 (Conference website) (Conference website)

Publication series

ISSN (Print)2325-8861


Conference41st Computing in Cardiology Conference, CinC 2014
Country/TerritoryUnited States
OtherComputing in Cardiology provides an international forum for scientists and professionals from the fields of medicine, physics, engineering and computer science, and has been held annually since 1974.
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