Multivessel coronary artery ectasia with severe calciﬁcation is rare among patients with coronary artery disease. A 74-year-old Chinese woman suffered from acute myocardial infarction on a background of 50 years of poorly controlled hypertension secondary to pheochromocytoma, which was surgically removed in June 2012 prior to the presentation. Coronary angiography revealed total occlusion of the proximal left anterior descending artery, and multiple ectasias with severe calciﬁcation in the left main, circumﬂex and right coronary artery. After an aspiration thrombectomyandballoonangioplasty,grade 3coronaryﬂowwas restoredin theleft descendingcoronaryartery.No cardiac events were found in the 12-month follow-up. We conclude that multivessel coronary artery ectasia and severe calciﬁcation may be present in patients with a long-standing history of hypertension secondary to pheochromocytoma.