Nasal cavity administration of melanin-concentrating hormone improves memory impairments in memory-impaired and Alzheimer’s disease mouse models

Seung Tack Oh, Quan Feng Liu, Ha Jin Jeong, Seongmi Lee, Manikandan Samidurai, Jihoon Jo, Sokcheon Pak, Hi Joon Park, Jongpil Kim, Songhee Jeon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Melanin-concentrating hormone (MCH) is a highly conserved neuropeptide known to exhibit important functions in the brain. Some studies have reported that MCH improves memory by promoting memory retention. However, the precise molecular mechanisms by which MCH enhances memory impairment have yet to be fully elucidated. In this study, MCH was administered to the scopolamine-induced memory-impaired mice via the nasal cavity to examine the acute effects of MCH and Alzheimer’s disease (AD) mouse models to evaluate the chronic effects of MCH. MCH improved memory impairment in both models and reduced soluble amyloid beta in the cerebral cortex of APP/PS1 transgenic mice. In vitro assays also showed that MCH inhibits amyloid beta-induced cytotoxicity. Furthermore, MCH increased long-term potentiation (LTP) in the hippocampus of wild-type and 5XFAD AD mouse model. To further elucidate the mechanisms of the chronic effect of MCH, the levels of phosphorylated CREB and GSK3β, and the expression of BDNF, TrkB and PSD95 were examined in the cerebral cortex and hippocampus. Our findings indicate that MCH might have neuroprotective effects via downstream pathways associated with the enhancement of neuronal synapses and LTP. This suggests a therapeutic potential of MCH for the treatment of neurodegenerative diseases such as AD.
Original languageEnglish
Pages (from-to)8076–8086
Number of pages11
JournalMolecular Neurobiology
Volume56
DOIs
Publication statusE-pub ahead of print - 10 Jun 2019

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