Navigating the Myriad of von Willebrand Factor Assays

Emmanuel J. Favaloro

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

von Willebrand factor (VWF) represents a large and complex adhesive plasma protein whose main function is to provide a bridge between blood platelets and damaged endothelium, and thus facilitate primary hemostasis. VWF also binds to FVIII, preventing early proteolysis, and delivers this cargo to sites of vascular injury, thereby promoting clot formation and secondary hemostasis. An absence, deficiency, or defect in VWF can lead to a bleeding diathesis called von Willebrand disease (VWD), considered the most common inherited bleeding disorder. Contemporary laboratory assays used in VWD diagnosis/exclusion comprise a myriad of assays that identify the quantity (level) of VWF, as well as the multitude of VWF activities. These may use the following test abbreviations: VWF:Ag, VWF:RCo, VWF:CB, VWF:GPIbR, VWF:GPIbM, VWF:FVIIB, VWF:Ab. The current review explains what these assays are, as well as their place in VWD diagnostics.

Original languageEnglish
Pages (from-to)431-442
Number of pages12
JournalHamostaseologie
Volume40
Issue number4
DOIs
Publication statusE-pub ahead of print - 26 Jun 2020

Fingerprint Dive into the research topics of 'Navigating the Myriad of von Willebrand Factor Assays'. Together they form a unique fingerprint.

Cite this