Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka

Risako Kabata, Shanika Nanayakkara, STMLD Senevirathna, Kouji H Harada, Rohana Chandrajith, Toshiaki Hitomi, Tilak Abeysekera, Takumi Takasuga, Akio Koizumi

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Abstract

Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed. Methods: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples. We selected 40 samples, 10 from farmers with CKDu and 10 from controls from each of two areas, Medawachchiya and Girandurukotte. Results: Imidacloprid and desmethyl-acetamiprid were found at significantly higher concentrations in the control samples (with medians of 51 ng/l and 340 ng/l, respectively) than in the CKDu samples (medians of 15 ng/l and 150 ng/l, respectively) when the results were not adjusted for the creatinine contents. None of the six compounds that were measured in the urine samples were found at significantly higher concentrations in the CKDu samples than in the control samples. None of the neonicotinoid concentrations in the samples analyzed in this study exceeded the concentrations that have been found in samples from the general population of Japan. Conclusions: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalJournal of Occupational Health
Volume58
Issue number1
Early online date2015
DOIs
Publication statusPublished - 2016

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Sri Lanka
Chronic Renal Insufficiency
Urine
Japan
Insecticides
Creatinine
Farmers
Population

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Kabata, Risako ; Nanayakkara, Shanika ; Senevirathna, STMLD ; Harada, Kouji H ; Chandrajith, Rohana ; Hitomi, Toshiaki ; Abeysekera, Tilak ; Takasuga, Takumi ; Koizumi, Akio. / Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka. In: Journal of Occupational Health. 2016 ; Vol. 58, No. 1. pp. 128-133.
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title = "Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka",
abstract = "Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed. Methods: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples. We selected 40 samples, 10 from farmers with CKDu and 10 from controls from each of two areas, Medawachchiya and Girandurukotte. Results: Imidacloprid and desmethyl-acetamiprid were found at significantly higher concentrations in the control samples (with medians of 51 ng/l and 340 ng/l, respectively) than in the CKDu samples (medians of 15 ng/l and 150 ng/l, respectively) when the results were not adjusted for the creatinine contents. None of the six compounds that were measured in the urine samples were found at significantly higher concentrations in the CKDu samples than in the control samples. None of the neonicotinoid concentrations in the samples analyzed in this study exceeded the concentrations that have been found in samples from the general population of Japan. Conclusions: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan.",
keywords = "Chronic kidney disease, Farmer, Neonicotinoid, Srilanka, Urine",
author = "Risako Kabata and Shanika Nanayakkara and STMLD Senevirathna and Harada, {Kouji H} and Rohana Chandrajith and Toshiaki Hitomi and Tilak Abeysekera and Takumi Takasuga and Akio Koizumi",
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Kabata, R, Nanayakkara, S, Senevirathna, STMLD, Harada, KH, Chandrajith, R, Hitomi, T, Abeysekera, T, Takasuga, T & Koizumi, A 2016, 'Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka', Journal of Occupational Health, vol. 58, no. 1, pp. 128-133. https://doi.org/10.1539/joh.15-0140-BR

Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka. / Kabata, Risako; Nanayakkara, Shanika; Senevirathna, STMLD; Harada, Kouji H; Chandrajith, Rohana; Hitomi, Toshiaki; Abeysekera, Tilak; Takasuga, Takumi; Koizumi, Akio.

In: Journal of Occupational Health, Vol. 58, No. 1, 2016, p. 128-133.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neonicotinoid concentrations in urine from chronic kidney disease patients in the north central region of Sri Lanka

AU - Kabata, Risako

AU - Nanayakkara, Shanika

AU - Senevirathna, STMLD

AU - Harada, Kouji H

AU - Chandrajith, Rohana

AU - Hitomi, Toshiaki

AU - Abeysekera, Tilak

AU - Takasuga, Takumi

AU - Koizumi, Akio

N1 - Includes bibliographical references.

PY - 2016

Y1 - 2016

N2 - Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed. Methods: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples. We selected 40 samples, 10 from farmers with CKDu and 10 from controls from each of two areas, Medawachchiya and Girandurukotte. Results: Imidacloprid and desmethyl-acetamiprid were found at significantly higher concentrations in the control samples (with medians of 51 ng/l and 340 ng/l, respectively) than in the CKDu samples (medians of 15 ng/l and 150 ng/l, respectively) when the results were not adjusted for the creatinine contents. None of the six compounds that were measured in the urine samples were found at significantly higher concentrations in the CKDu samples than in the control samples. None of the neonicotinoid concentrations in the samples analyzed in this study exceeded the concentrations that have been found in samples from the general population of Japan. Conclusions: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan.

AB - Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed. Methods: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples. We selected 40 samples, 10 from farmers with CKDu and 10 from controls from each of two areas, Medawachchiya and Girandurukotte. Results: Imidacloprid and desmethyl-acetamiprid were found at significantly higher concentrations in the control samples (with medians of 51 ng/l and 340 ng/l, respectively) than in the CKDu samples (medians of 15 ng/l and 150 ng/l, respectively) when the results were not adjusted for the creatinine contents. None of the six compounds that were measured in the urine samples were found at significantly higher concentrations in the CKDu samples than in the control samples. None of the neonicotinoid concentrations in the samples analyzed in this study exceeded the concentrations that have been found in samples from the general population of Japan. Conclusions: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan.

KW - Chronic kidney disease

KW - Farmer

KW - Neonicotinoid

KW - Srilanka

KW - Urine

U2 - 10.1539/joh.15-0140-BR

DO - 10.1539/joh.15-0140-BR

M3 - Article

C2 - 26549834

VL - 58

SP - 128

EP - 133

JO - Journal of Occupational Health

JF - Journal of Occupational Health

SN - 1341-9145

IS - 1

ER -