Neuroinflammation, cortical activity, and fatiguing behaviour during self-paced exercise

Nicole Vargas, Frank Marino

Research output: Contribution to journalArticle

2 Citations (Scopus)


The present study aimed to identify whether or not the release of interleukin (IL)-6 and soluble (s) IL-6 receptor (R) is associated with fatiguing behaviour and changes in cortical activity during self-paced exercise. Relationships between the IL-6 and its soluble receptors, total work, reductions in power output, and changes in slow, alpha (α) and fast, beta (β) brain waves during self-paced exercise were evaluated. Different intensities and environments were used to manipulate the release of IL-6, whereby seven active males cycled for 60 min in heat stress (HS) or thermoneutral (TN) environments at a clamped rating of perceived exertion (RPE) equating to low intensity (RPE = 12) or high intensity (RPE = 16). IL-6 and sIL-6R were positively associated with total work, but not with reductions in power output. There was greater α activity in high-intensity conditions, which was associated with the reduction in power output. Both high-intensity conditions appeared to have greater β activity, and there was a positive correlation between β activity and total work and β activity and sIL-6R. We conclude that IL-6 and sIL-6R may contribute to perturbations in cortical activity and are associated with total work output, but reductions in power output are likely influenced greater by other internal and external factors.
Original languageEnglish
Pages (from-to)413-426
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Issue number2
Early online dateNov 2017
Publication statusPublished - Feb 2018

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