TY - JOUR
T1 - Neuroinflammation, cortical activity, and fatiguing behaviour during self-paced exercise
AU - Vargas, Nicole
AU - Marino, Frank
N1 - Includes bibliographical references.
PY - 2018/2
Y1 - 2018/2
N2 - The present study aimed to identify whether or not the release of interleukin (IL)-6 and soluble (s) IL-6 receptor (R) is associated with fatiguing behaviour and changes in cortical activity during self-paced exercise. Relationships between the IL-6 and its soluble receptors, total work, reductions in power output, and changes in slow, alpha (α) and fast, beta (β) brain waves during self-paced exercise were evaluated. Different intensities and environments were used to manipulate the release of IL-6, whereby seven active males cycled for 60 min in heat stress (HS) or thermoneutral (TN) environments at a clamped rating of perceived exertion (RPE) equating to low intensity (RPE = 12) or high intensity (RPE = 16). IL-6 and sIL-6R were positively associated with total work, but not with reductions in power output. There was greater α activity in high-intensity conditions, which was associated with the reduction in power output. Both high-intensity conditions appeared to have greater β activity, and there was a positive correlation between β activity and total work and β activity and sIL-6R. We conclude that IL-6 and sIL-6R may contribute to perturbations in cortical activity and are associated with total work output, but reductions in power output are likely influenced greater by other internal and external factors.
AB - The present study aimed to identify whether or not the release of interleukin (IL)-6 and soluble (s) IL-6 receptor (R) is associated with fatiguing behaviour and changes in cortical activity during self-paced exercise. Relationships between the IL-6 and its soluble receptors, total work, reductions in power output, and changes in slow, alpha (α) and fast, beta (β) brain waves during self-paced exercise were evaluated. Different intensities and environments were used to manipulate the release of IL-6, whereby seven active males cycled for 60 min in heat stress (HS) or thermoneutral (TN) environments at a clamped rating of perceived exertion (RPE) equating to low intensity (RPE = 12) or high intensity (RPE = 16). IL-6 and sIL-6R were positively associated with total work, but not with reductions in power output. There was greater α activity in high-intensity conditions, which was associated with the reduction in power output. Both high-intensity conditions appeared to have greater β activity, and there was a positive correlation between β activity and total work and β activity and sIL-6R. We conclude that IL-6 and sIL-6R may contribute to perturbations in cortical activity and are associated with total work output, but reductions in power output are likely influenced greater by other internal and external factors.
KW - Behaviour
KW - Cortical activity
KW - Exercise
KW - Fatigue
KW - Interleukin-6
KW - Soluble interleukin-6 receptor
UR - http://www.scopus.com/inward/record.url?scp=85034586134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034586134&partnerID=8YFLogxK
U2 - 10.1007/s00424-017-2086-8
DO - 10.1007/s00424-017-2086-8
M3 - Article
C2 - 29159538
AN - SCOPUS:85034586134
SN - 0031-6768
VL - 470
SP - 413
EP - 426
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
IS - 2
ER -