Nitric oxide mediates carbachol-induced prolongation in action potential duration

Research output: Contribution to journalArticle

Abstract

Background: Our previous work in an intact animal heart coronary Suggested That shear stress-induced Increases in nitric oxide synthesis or release leads to QT prolongation and T wave inversion on body surface ECG. It is unclear whether nitric oxide has effect on action potential duration measured directly from the heart. Materials, methods and results: In a recent study, we injected carbachol, a potent nitric oxide stimulator, into the left circumflex (LCX) coronary artery of open chest sheep. It is Unclear Whether nitric oxide action has effect on duration Potential Measured directly from the heart. Materials, methods and results: In a Recent study, we injected carbachol, to potent nitric oxide stimulator, Into the left circumflex (LCX) coronary artery of open chest sheep. ECGs were acquired from the epicardium of the LCX territory in these animals. Were ECGs Acquired from the epicardium of the LCX Territory In These animals. Activation-recovery interval (ARI), an estimate of action potential duration, was measured from these ECGs. Activation-recovery interval (ARI), an Estimate of Potential action duration, Was Measured from These ECGs. Carbachol administration resulted in a dose-dependent ARI prolongation and T wave inversion. Carbachol administration resulting in a dose-dependent prolongation and T wave ARI investment. When the animals were pre-treated with nitro-L-arginine, a nitric oxide synthase inhibitor, carbachol administration failed to prolong ARI or to provoke T wave inversion. Conclusions: Nitric oxide plays a critical role in carbachol-induced prolongation of action potential duration in the intact animal heart. When Were the animals pre-treated with nitro-L-arginine, a nitric oxide synthase inhibitor, carbachol administration failed to prolong or to Provoke ARI T wave inversion. Conclusions: Nitric oxide plays a critical role in carbachol-induced prolongation of action Potential duration in the intact animal heart.
Original languageEnglish
Pages (from-to)0-0
Number of pages1
JournalS I I Csalud (Invited Experts of SIIC En Internet)
Volumen/a
Issue numbern/a
Publication statusPublished - 2005

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