Normobaric hyperoxic stress in budgerigars: Non-enzymic antioxidants

S. Jaensch, L. Cullen, L. Morton, S. R. Raidal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of oxygen exposure on pulmonary and blood non-enzymic antioxidant concentrations was evaluated in budgerigars (Melopsittacus undulatus). Budgerigars were exposed to acute (3 h), repeated acute (3 exposures each of 3 h) or chronic (72 h) normobaric hyperoxic environments and the pulmonary and plasma concentrations of selected non-enzymic antioxidants, namely glutathione, uric acid, α- and γ-tocopherol and carotenoids were assayed. With increasing duration of oxygen exposure, the ratio of oxidised to reduced glutathione was significantly increased, while the concentrations of uric acid, α- and γ-tocopherol and carotenoids were significantly reduced, especially following chronic oxygen exposure. Following acute and repeated acute exposure, alteration in glutathione concentrations and reduction in α-tocopherol concentrations indicated oxygen stress. Following chronic exposure, depletion of non-enzymic antioxidants indicated exhaustion of these protective mechanisms and progression from oxygen stress to oxygen toxicity.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalComparative Biochemistry and Physiology - C Toxicology and Pharmacology
Volume128
Issue number3
Publication statusPublished - 15 May 2001

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