Omega-3 supplementation in juvenile bipolar disorder

Tanya L. Hanstock, Stehen J. Hirneth, Colin J. Kable, Manohar L. Garg, Philip L. Hazell, Edward Clayton

Research output: Book chapter/Published conference paperConference paper

Abstract

Background: Supplementation with long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may be beneficial in the treatment of depression in children and bipolar disorder (BD) in adults. Aims: To examine the change in symptoms of mania and depression in participants with juvenile BD (JBD) following supplementation with LCn-3PUFA. Method: Eighteen participants with JBD received supplements containing 1.92 g day 1 LCn-3PUFA, including 360 mg day 1 EPA and 1560 mg day 1 DHA, for 6 weeks. Fasting Red Blood Cell (RBC) LCn-3PUFA, mania, depression and global function were measured before and after supplementation. Results: RBC EPA and DHA increased significantly following supplementation. Symptoms of mania and depression were significantly lower and global functioning was significantly higher following supplementation. Changes in RBC LCn-3PUFA were not significantly related to changes in mania or depression. Conclusion: Supplementation with omega-3 was associated with a reduction in mania and depression in participants with JBD when given in an open-label manner. A larger randomised controlled trial appears warranted in this participant population.
Original languageEnglish
Title of host publicationAustraliasian Society for Psychiatric Research
EditorsPeter Joyce
Place of PublicationLondon
PublisherInforma Healthcare USA
PagesA45
Volume42
Publication statusPublished - 2008
EventAustralian and New Zealand Journal of Psychiatry - Newcastle
Duration: 02 Dec 200805 Dec 2008

Conference

ConferenceAustralian and New Zealand Journal of Psychiatry
Period02/12/0805/12/08

Fingerprint Dive into the research topics of 'Omega-3 supplementation in juvenile bipolar disorder'. Together they form a unique fingerprint.

  • Cite this

    Hanstock, T. L., Hirneth, S. J., Kable, C. J., Garg, M. L., Hazell, P. L., & Clayton, E. (2008). Omega-3 supplementation in juvenile bipolar disorder. In P. Joyce (Ed.), Australiasian Society for Psychiatric Research (Vol. 42, pp. A45). Informa Healthcare USA.