Abstract
Background: Supplementation with long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may be beneficial in the treatment of depression in children and bipolar disorder (BD) in adults. Aims: To examine the change in symptoms of mania and depression in participants with juvenile BD (JBD) following supplementation with LCn-3PUFA. Method: Eighteen participants with JBD received supplements containing 1.92 g day 1 LCn-3PUFA, including 360 mg day 1 EPA and 1560 mg day 1 DHA, for 6 weeks. Fasting Red Blood Cell (RBC) LCn-3PUFA, mania, depression and global function were measured before and after supplementation. Results: RBC EPA and DHA increased significantly following supplementation. Symptoms of mania and depression were significantly lower and global functioning was significantly higher following supplementation. Changes in RBC LCn-3PUFA were not significantly related to changes in mania or depression. Conclusion: Supplementation with omega-3 was associated with a reduction in mania and depression in participants with JBD when given in an open-label manner. A larger randomised controlled trial appears warranted in this participant population.
| Original language | English |
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| Title of host publication | Australiasian Society for Psychiatric Research |
| Editors | Peter Joyce |
| Place of Publication | London |
| Publisher | Informa Healthcare USA |
| Pages | A45 |
| Volume | 42 |
| Publication status | Published - 2008 |
| Event | Australian and New Zealand Journal of Psychiatry - Newcastle Duration: 02 Dec 2008 → 05 Dec 2008 |
Conference
| Conference | Australian and New Zealand Journal of Psychiatry |
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| Period | 02/12/08 → 05/12/08 |