TY - CHAP
T1 - Optimizing the verification of mean normal prothrombin time (MNPT) and international sensitivity index (ISI) for accurate conversion of prothrombin time (PT) to international normalized ratio (INR)
AU - Favaloro, Emmanuel J
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media LLC.
PY - 2017
Y1 - 2017
N2 - The Prothrombin Time (PT) assay is the most common test performed in hemostasis laboratories, most commonly as converted to an international normalized ratio (INR) to monitor anticoagulant therapy using vitamin K antagonists (VKAs) such as warfarin. Although the INR is meant to standardize PT values by taking into consideration reagent and instrument variability, substantial inter-laboratory variation in INRs still exists and suggests that this can be further improved. This paper describes the PT test, its conversion to an INR value, and methods to improve the accuracy of INRs by improving the determination of critical components to the INR, namely the mean normal prothrombin time (MNPT) and the international sensitive index (ISI).
AB - The Prothrombin Time (PT) assay is the most common test performed in hemostasis laboratories, most commonly as converted to an international normalized ratio (INR) to monitor anticoagulant therapy using vitamin K antagonists (VKAs) such as warfarin. Although the INR is meant to standardize PT values by taking into consideration reagent and instrument variability, substantial inter-laboratory variation in INRs still exists and suggests that this can be further improved. This paper describes the PT test, its conversion to an INR value, and methods to improve the accuracy of INRs by improving the determination of critical components to the INR, namely the mean normal prothrombin time (MNPT) and the international sensitive index (ISI).
KW - International normalized ratio (INR)
KW - International sensitive index (ISI)
KW - Mean normal prothrombin time (MNPT)
KW - Prothrombin time (PT)
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U2 - 10.1007/978-1-4939-7196-1_4
DO - 10.1007/978-1-4939-7196-1_4
M3 - Chapter (peer-reviewed)
C2 - 28804818
SN - 9781493971947
VL - 1646
T3 - Methods in Molecular Biology
SP - 59
EP - 74
BT - Methods in Molecular Biology
A2 - Favaloro, Emmanuel J.
A2 - Lippi, Giuseppe
PB - Humana Press
ER -