Optimizing the verification of mean normal prothrombin time (MNPT) and international sensitivity index (ISI) for accurate conversion of prothrombin time (PT) to international normalized ratio (INR)

Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

15 Citations (Scopus)

Abstract

The Prothrombin Time (PT) assay is the most common test performed in hemostasis laboratories, most commonly as converted to an international normalized ratio (INR) to monitor anticoagulant therapy using vitamin K antagonists (VKAs) such as warfarin. Although the INR is meant to standardize PT values by taking into consideration reagent and instrument variability, substantial inter-laboratory variation in INRs still exists and suggests that this can be further improved. This paper describes the PT test, its conversion to an INR value, and methods to improve the accuracy of INRs by improving the determination of critical components to the INR, namely the mean normal prothrombin time (MNPT) and the international sensitive index (ISI).
Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsEmmanuel J. Favaloro, Giuseppe Lippi
PublisherHumana Press
Chapter4
Pages59-74
Number of pages16
Volume1646
ISBN (Electronic)9781493971961
ISBN (Print)9781493971947
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1646
ISSN (Print)1064-3745

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