Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters

Jacob G. Zeevaart, Christopher J. Parkinson, Charles B. De Koning

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K3PO4 is described. The arylated acetoacetate ester is de-acylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters.

Original languageEnglish
Pages (from-to)4261-4264
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number22
DOIs
Publication statusPublished - 24 May 2004

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