Pathotyping of Australian isolates of Marek's disease virus.

Steve Walken-Brown, Julie Cooke, Aminul Islam, Katrin Renz, Zahid Hussain, Fakhrul Islam, Greg Tannock, Peter Groves

Research output: Book chapter/Published conference paperConference paperpeer-review

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Marek's disease has changed significantly since it was first described, with markedincreases in the virulence of Marek's disease virus (MDV) evident in some countries both prior to,and following, the introduction of vaccination in 1970 . Increases in virulence have beenassociated with sequential vaccine failure, and a MDV pathotyping scheme based on theprotective index provided by HVT and HVT/MDV2 bivalent vaccines was developed at the USDAAvian Diseases and Oncology Laboratory (ADOL) and later adapted to enable easierinternational comparison of isolates . The original method involves administration of a fixedchallenge of MDV to a defined susceptible genotype of chicken (line 15x7 cross) with maternalantibody against MDV. Viruses are classified under this as shown in Table 1.
Original languageEnglish
Title of host publicationProceedings Australian Veterinary Poultry Alliance
Place of PublicationAustralia
PublisherPoultry Hub
Number of pages6
Publication statusPublished - 2007
EventAustralian Veterinary Poultry Alliance -
Duration: 13 Feb 2007 → …


ConferenceAustralian Veterinary Poultry Alliance
Period13/02/07 → …


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