Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress

J. W. Crane, K.R. French, K.M. Buller

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

By most accounts the psychological stressor restraint produces a distinct pattern of neuronal activation in the brain. However, some evidence is incongruous with this pattern, leading us to propose that the restraint-induced pattern in the central nervous system might depend on the duration of restraint used. We therefore determined the pattern of neuronal activation (as indicated by the presence of Fos protein) seen in the paraventricular nucleus (PVN), bed nucleus of the stria terminalis, amygdala, locus coeruleus, nucleus tractus solitarius (NTS), ventrolateral medulla (VLM) and thoracic spinal cord of the rat in response to 0, 15, 30 or 60 min periods of restraint. We found that although a number of cell groups displayed a linear increase in activity with increasing durations of restraint (e.g. hypothalamic corticotrophin-releasing factor (CRF) cells, medial amygdala neurons and sympathetic preganglionic neurons of the thoracic spinal cord), a number of cell groups did not. For example, in the central amygdala restraint produced both a decrease in CRF cell activity and an increase in non-CRF cell activity. In the locus coeruleus, noradrenergic neurons did not display Fos in response to 15 min of restraint, but were significantly activated by 30 or 60 min restraint. After 30 or 60 min restraint a greater degree of activation of more rostral A1 noradrenergic neurons was observed compared with the pattern of A1 noradrenergic neurons in response to 15 min restraint. The results of this study demonstrate that restraint stress duration determines the amount and the pattern of neuronal activation seen in response to this psychological stressor.
Original languageEnglish
Pages (from-to)199-211
Number of pages13
JournalStress
Volume8
Issue number3
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Adrenergic Neurons
Spinal Cord
Locus Coeruleus
Corticotropin-Releasing Hormone
Amygdala
Brain
Thorax
Cell Count
Psychology
Pituitary Hormone-Releasing Hormones
Neurons
Septal Nuclei
Solitary Nucleus
Paraventricular Hypothalamic Nucleus
Central Nervous System
Proteins

Cite this

Crane, J. W. ; French, K.R. ; Buller, K.M. / Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress. In: Stress. 2005 ; Vol. 8, No. 3. pp. 199-211.
@article{e6dd17d84126426e94f02cd64cbaf4c0,
title = "Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress",
abstract = "By most accounts the psychological stressor restraint produces a distinct pattern of neuronal activation in the brain. However, some evidence is incongruous with this pattern, leading us to propose that the restraint-induced pattern in the central nervous system might depend on the duration of restraint used. We therefore determined the pattern of neuronal activation (as indicated by the presence of Fos protein) seen in the paraventricular nucleus (PVN), bed nucleus of the stria terminalis, amygdala, locus coeruleus, nucleus tractus solitarius (NTS), ventrolateral medulla (VLM) and thoracic spinal cord of the rat in response to 0, 15, 30 or 60 min periods of restraint. We found that although a number of cell groups displayed a linear increase in activity with increasing durations of restraint (e.g. hypothalamic corticotrophin-releasing factor (CRF) cells, medial amygdala neurons and sympathetic preganglionic neurons of the thoracic spinal cord), a number of cell groups did not. For example, in the central amygdala restraint produced both a decrease in CRF cell activity and an increase in non-CRF cell activity. In the locus coeruleus, noradrenergic neurons did not display Fos in response to 15 min of restraint, but were significantly activated by 30 or 60 min restraint. After 30 or 60 min restraint a greater degree of activation of more rostral A1 noradrenergic neurons was observed compared with the pattern of A1 noradrenergic neurons in response to 15 min restraint. The results of this study demonstrate that restraint stress duration determines the amount and the pattern of neuronal activation seen in response to this psychological stressor.",
author = "Crane, {J. W.} and K.R. French and K.M. Buller",
note = "Imported on 12 Apr 2017 - DigiTool details were: month (773h) = September, 2005; Journal title (773t) = Stress: the International Journal on the Biology of Stress. ISSNs: 1025-3890;",
year = "2005",
month = "9",
doi = "10.1080/10253890500333817",
language = "English",
volume = "8",
pages = "199--211",
journal = "Stress",
issn = "1025-3890",
publisher = "Informa Healthcare USA",
number = "3",

}

Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress. / Crane, J. W.; French, K.R.; Buller, K.M.

In: Stress, Vol. 8, No. 3, 09.2005, p. 199-211.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Patterns of neuronal activation in the rat brain and spinal cord in response to increasing durations of restraint stress

AU - Crane, J. W.

AU - French, K.R.

AU - Buller, K.M.

N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = September, 2005; Journal title (773t) = Stress: the International Journal on the Biology of Stress. ISSNs: 1025-3890;

PY - 2005/9

Y1 - 2005/9

N2 - By most accounts the psychological stressor restraint produces a distinct pattern of neuronal activation in the brain. However, some evidence is incongruous with this pattern, leading us to propose that the restraint-induced pattern in the central nervous system might depend on the duration of restraint used. We therefore determined the pattern of neuronal activation (as indicated by the presence of Fos protein) seen in the paraventricular nucleus (PVN), bed nucleus of the stria terminalis, amygdala, locus coeruleus, nucleus tractus solitarius (NTS), ventrolateral medulla (VLM) and thoracic spinal cord of the rat in response to 0, 15, 30 or 60 min periods of restraint. We found that although a number of cell groups displayed a linear increase in activity with increasing durations of restraint (e.g. hypothalamic corticotrophin-releasing factor (CRF) cells, medial amygdala neurons and sympathetic preganglionic neurons of the thoracic spinal cord), a number of cell groups did not. For example, in the central amygdala restraint produced both a decrease in CRF cell activity and an increase in non-CRF cell activity. In the locus coeruleus, noradrenergic neurons did not display Fos in response to 15 min of restraint, but were significantly activated by 30 or 60 min restraint. After 30 or 60 min restraint a greater degree of activation of more rostral A1 noradrenergic neurons was observed compared with the pattern of A1 noradrenergic neurons in response to 15 min restraint. The results of this study demonstrate that restraint stress duration determines the amount and the pattern of neuronal activation seen in response to this psychological stressor.

AB - By most accounts the psychological stressor restraint produces a distinct pattern of neuronal activation in the brain. However, some evidence is incongruous with this pattern, leading us to propose that the restraint-induced pattern in the central nervous system might depend on the duration of restraint used. We therefore determined the pattern of neuronal activation (as indicated by the presence of Fos protein) seen in the paraventricular nucleus (PVN), bed nucleus of the stria terminalis, amygdala, locus coeruleus, nucleus tractus solitarius (NTS), ventrolateral medulla (VLM) and thoracic spinal cord of the rat in response to 0, 15, 30 or 60 min periods of restraint. We found that although a number of cell groups displayed a linear increase in activity with increasing durations of restraint (e.g. hypothalamic corticotrophin-releasing factor (CRF) cells, medial amygdala neurons and sympathetic preganglionic neurons of the thoracic spinal cord), a number of cell groups did not. For example, in the central amygdala restraint produced both a decrease in CRF cell activity and an increase in non-CRF cell activity. In the locus coeruleus, noradrenergic neurons did not display Fos in response to 15 min of restraint, but were significantly activated by 30 or 60 min restraint. After 30 or 60 min restraint a greater degree of activation of more rostral A1 noradrenergic neurons was observed compared with the pattern of A1 noradrenergic neurons in response to 15 min restraint. The results of this study demonstrate that restraint stress duration determines the amount and the pattern of neuronal activation seen in response to this psychological stressor.

U2 - 10.1080/10253890500333817

DO - 10.1080/10253890500333817

M3 - Article

VL - 8

SP - 199

EP - 211

JO - Stress

JF - Stress

SN - 1025-3890

IS - 3

ER -