PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic - pituitary - adrenal axis?

Suhail AR Doi, Philip Towers, Christopher Scott, Kamal AS Al-Shoumer

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This review focuses on the role of the ovaries in the pathogenesis of the polycystic ovarian syndrome. In particular, the failure of follicular development, hypothalamo-pituitary dysregulation, alterations in adrenal steroid output and derangement of intermediary metabolism are discussed in the context of the ovaries. It is concluded that the central and adrenal alterations associated with PCOS are unlikely to be primary but rather are secondary to the events within the ovary.
Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume118
Issue number1
DOIs
Publication statusPublished - 2005

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