Pearls and pitfalls in factor inhibitor assays

D M Adcock, E J Favaloro

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

The proper performance and interpretation of factor inhibitor assays is a critical role for the hemostasis laboratory. Both false-positive and false-negative inhibitor assays may be reported, leading to serious patient mismanagement. Knowledge and recognition of common causes of both false-positive and negative-results can aid in the identification of these potential pitfalls. Safeguards to reporting accurate factor inhibitor assays include initial characterization of the sample, using the Nijmegen modification, properly performing and interpreting an incubated mixing test in conjunction, and performing two dilutions for each dependent dilution in the factor inhibitor assay.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalInternational Journal of Laboratory Hematology
Volume37 Suppl 1
DOIs
Publication statusPublished - May 2015

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