TY - JOUR
T1 - Pediatric brown adipose tissue on 18F-FDG PET
T2 - Diazepam intervention
AU - Cousins, Justine
AU - Czachowski, Michael
AU - Muthukrishnan, Ashok
AU - Currie, Geoff
N1 - Includes bibliographical references.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Brown adipose tissue (BAT) has been widely reported to affect the efficacy of 18F-FDG PET in oncology. Several small studies have found that warming the patient both before 18F-FDG injection and during the uptake phase can reduce the frequency of BAT uptake. Pharmaceutical approaches such as propranolol and diazepam have also been used. Methods: We describe two case studies that demonstrated the impact of combined patient warming and diazepam administration on BAT uptake in pediatric 18F-FDG PET images. To support these findings, we performed a retrospective analysis of 139 patients: 71 who received warming only and 68 who received warming combined with diazepam. Results: BAT uptake was significantly less frequent in patients who received diazepam (16.2%) than in those who did not (33.8%) (P = 0.0167), particularly in female patients (7.4% vs. 26.7%) (P = 0.0486). Conclusion: Although patient warming alone reduces the frequency of BAT uptake, the addition of diazepam to patient warming significantly furthers the reduction in young patients, particularly female patients.
AB - Brown adipose tissue (BAT) has been widely reported to affect the efficacy of 18F-FDG PET in oncology. Several small studies have found that warming the patient both before 18F-FDG injection and during the uptake phase can reduce the frequency of BAT uptake. Pharmaceutical approaches such as propranolol and diazepam have also been used. Methods: We describe two case studies that demonstrated the impact of combined patient warming and diazepam administration on BAT uptake in pediatric 18F-FDG PET images. To support these findings, we performed a retrospective analysis of 139 patients: 71 who received warming only and 68 who received warming combined with diazepam. Results: BAT uptake was significantly less frequent in patients who received diazepam (16.2%) than in those who did not (33.8%) (P = 0.0167), particularly in female patients (7.4% vs. 26.7%) (P = 0.0486). Conclusion: Although patient warming alone reduces the frequency of BAT uptake, the addition of diazepam to patient warming significantly furthers the reduction in young patients, particularly female patients.
KW - F-FDG PET
KW - BAT
KW - Brown fat
KW - Diazepam
UR - http://www.scopus.com/inward/record.url?scp=85020077062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020077062&partnerID=8YFLogxK
U2 - 10.2967/jnmt.116.187385
DO - 10.2967/jnmt.116.187385
M3 - Article
C2 - 28280132
AN - SCOPUS:85020077062
SN - 0091-4916
VL - 45
SP - 82
EP - 86
JO - Journal of Nuclear Medicine Technology
JF - Journal of Nuclear Medicine Technology
IS - 2
ER -