This commentary offers a contemporary perspective on personalised medicine (PM) within diagnostic radiography. PM refers to the use of a person's genetic information in tailoring strategies for the detection, treatment, or prevention of disease. Some key issues are raised in light of this new specialty and how it may affect diagnostic imaging. First, technological and commercial drivers are outlined, supported with ethical considerations. The authors then offer some future challenges that remain evident within the literature. The aim of this article is to begin to acknowledge the importance of PM, but most importantly, identify aspects where diagnostic imaging plays a pivotal role.