PET/MRI part 3: Protocols and procedures

The emergence of PET and MRI as a hybrid modality has demanded new approaches to protocols and procedures. Although protocols for MRI and PET individually lend themselves to synergistic and simultaneous approaches, there are a number of unique challenges and patient preparations that require consideration. This article provides insight into the protocols, procedures, and challenges associated with simultaneous PET/MRI in both adult and pediatric populations. Although protocols may be specific to applications or pathologies of interest, a richer discussion of the clinical applications of PET/MRI is beyond the scope of this article and will be detailed in part 4 of the series. The foundation of PET/MRI protocols is an understanding of the various MRI sequences, which are outlined succinctly. The principles outlined for protocols and procedures are general, and specific application will vary among departments. Given that the procedures for PET are well established among the readership of this journal, this article emphasizes MRI factors unless specific variations in standard PET protocols or procedures are driven by the simultaneous MRI. This article is the third in a 4-part integrated series sponsored by the PET/MR and Publication Committees of the Society of Nuclear Medicine and Molecular Imaging–Technologist Section.