PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

Bashar Thejer, Partho Adhikary, Amandeep Kaur, Sarah Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Katharine M. Hannan, Megan Pavy, Perlita Poh, Jalal Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan C. Cassano, Lynne Turnbull, Mitra Jazayeri, Alexander C. James, Craig P. CooreyTara L Roberts, Simon J. Kinder, Ross D. Hannan, Ellis Patrick, Mark P Molloy, Elizabeth J. New, Tanja Fehm, Hans Neubauer, Ewa M. Goldys, Leslie A Weston, Michael A. Cahill

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms.
Original languageEnglish
Article number24
Pages (from-to)1-24
Number of pages24
JournalBMC Molecular and Cell Biology
Volume21
DOIs
Publication statusPublished - 03 Apr 2020

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