Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation

Tong-Wen Sun, Shou-Yan Zhang, Lexin Wang

Research output: Contribution to journalArticle

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7 Downloads (Pure)

Abstract

B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.
Original languageEnglish
Pages (from-to)1160-1162
Number of pages3
JournalMedical Hypotheses
Volume70
Issue number6
DOIs
Publication statusPublished - 2008

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Brain Natriuretic Peptide
Kidney Transplantation
Allografts
Early Diagnosis
Kidney
Muscle Cells
Chronic Kidney Failure
Biomarkers

Cite this

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title = "Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation",
abstract = "B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.",
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Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation. / Sun, Tong-Wen; Zhang, Shou-Yan; Wang, Lexin.

In: Medical Hypotheses, Vol. 70, No. 6, 2008, p. 1160-1162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation

AU - Sun, Tong-Wen

AU - Zhang, Shou-Yan

AU - Wang, Lexin

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Medical Hypotheses. ISSNs: 0306-9877;

PY - 2008

Y1 - 2008

N2 - B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.

AB - B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.

KW - Open access version available

KW - Acute allograft renal rejection

KW - B-type natriuretic peptide

KW - Kidney

KW - Renal transplantation

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