Plasma B-type natriuretic peptide for early diagnosis of allograft rejection after renal transplantation

Tong-Wen Sun, Shou-Yan Zhang, Lexin Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)
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Abstract

B-type natriuretic peptides are predominantly synthesized in the ventricular myocytes. This is the response to volume overload or increased stress to the ventricular wall. Plasma B-type natriuretic peptide levels are elevated in patients with chronic renal failure due to reduced glomerular filtration and/or increased myocardial biosynthesis. Allograft renal transplantation significantly reduces plasma B-type natriuretic peptide. Our previous clinical observations have demonstrated that acute allograft renal rejection is associated with a sudden increase in plasma B-type natriuretic peptides. We hypothesized that plasma B-type natriuretic peptide may be used as a sensitive and specific biomarker for clinical diagnosis of acute allograft renal rejection.
Original languageEnglish
Pages (from-to)1160-1162
Number of pages3
JournalMedical Hypotheses
Volume70
Issue number6
DOIs
Publication statusPublished - 2008

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