Polyphenols from Australian-grown pigmented red and purple rice inhibit adipocyte differentiation

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Abstract

Coloured rice is rich in polyphenols and has been shown to have significant antioxidant and anti-adipogenic potential. The study aimed to investigate the anti-adipogenic properties of polyphenol extract (PE) derived from Australian-grown rice varieties. Eight wholegrain pigmented rice varieties were screened for their polyphenol content and antioxidant activity, of which, Yunlu29 (red), Purple (purple) and Reiziq (brown) had the highest values. The selected varieties were then subjected to in-vitro investigation to determine the effect of rice-derived PE on adipocyte differentiation. Lipid accumulation and peroxisome proliferator-activated receptor gamma (PPARγ) expression were quantified by oil red O staining and RT-PCR respectively. PE from Yunlu29 (red) and Purple rice varieties significantly reduced (p < 0.001) lipid accumulation by 53% and 56% respectively and PPARγ expression in adipocytes by 61.2% and 35.6% respectively. PE from Reiziq (brown), did not inhibit lipid accumulation in adipocytes however, did reduce PPARγ expression (p < 0.001).
Original languageEnglish
Pages (from-to)140-146
Number of pages6
JournalJournal of Cereal Science
Volume81
DOIs
Publication statusPublished - May 2018

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Polyphenols
adipocytes
Adipocytes
polyphenols
rice
PPAR gamma
extracts
Lipids
lipids
Antioxidants
Oryza
antioxidant activity
reverse transcriptase polymerase chain reaction
Staining and Labeling
antioxidants
Polymerase Chain Reaction
oils
peroxisome proliferator-activated receptors

Grant Number

  • IC140100027

Cite this

@article{3b527174b2174c0f91b8a30aaf7b9f16,
title = "Polyphenols from Australian-grown pigmented red and purple rice inhibit adipocyte differentiation",
abstract = "Coloured rice is rich in polyphenols and has been shown to have significant antioxidant and anti-adipogenic potential. The study aimed to investigate the anti-adipogenic properties of polyphenol extract (PE) derived from Australian-grown rice varieties. Eight wholegrain pigmented rice varieties were screened for their polyphenol content and antioxidant activity, of which, Yunlu29 (red), Purple (purple) and Reiziq (brown) had the highest values. The selected varieties were then subjected to in-vitro investigation to determine the effect of rice-derived PE on adipocyte differentiation. Lipid accumulation and peroxisome proliferator-activated receptor gamma (PPARγ) expression were quantified by oil red O staining and RT-PCR respectively. PE from Yunlu29 (red) and Purple rice varieties significantly reduced (p < 0.001) lipid accumulation by 53{\%} and 56{\%} respectively and PPARγ expression in adipocytes by 61.2{\%} and 35.6{\%} respectively. PE from Reiziq (brown), did not inhibit lipid accumulation in adipocytes however, did reduce PPARγ expression (p < 0.001).",
author = "Esther Callcott and Abishek Santhakumar and Padraig Strappe and Jixun Luo and Christopher Blanchard",
year = "2018",
month = "5",
doi = "10.1016/j.jcs.2018.04.011",
language = "English",
volume = "81",
pages = "140--146",
journal = "Journal of Cereal Science",
issn = "0733-5210",
publisher = "Academic Press",

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TY - JOUR

T1 - Polyphenols from Australian-grown pigmented red and purple rice inhibit adipocyte differentiation

AU - Callcott, Esther

AU - Santhakumar, Abishek

AU - Strappe, Padraig

AU - Luo, Jixun

AU - Blanchard, Christopher

PY - 2018/5

Y1 - 2018/5

N2 - Coloured rice is rich in polyphenols and has been shown to have significant antioxidant and anti-adipogenic potential. The study aimed to investigate the anti-adipogenic properties of polyphenol extract (PE) derived from Australian-grown rice varieties. Eight wholegrain pigmented rice varieties were screened for their polyphenol content and antioxidant activity, of which, Yunlu29 (red), Purple (purple) and Reiziq (brown) had the highest values. The selected varieties were then subjected to in-vitro investigation to determine the effect of rice-derived PE on adipocyte differentiation. Lipid accumulation and peroxisome proliferator-activated receptor gamma (PPARγ) expression were quantified by oil red O staining and RT-PCR respectively. PE from Yunlu29 (red) and Purple rice varieties significantly reduced (p < 0.001) lipid accumulation by 53% and 56% respectively and PPARγ expression in adipocytes by 61.2% and 35.6% respectively. PE from Reiziq (brown), did not inhibit lipid accumulation in adipocytes however, did reduce PPARγ expression (p < 0.001).

AB - Coloured rice is rich in polyphenols and has been shown to have significant antioxidant and anti-adipogenic potential. The study aimed to investigate the anti-adipogenic properties of polyphenol extract (PE) derived from Australian-grown rice varieties. Eight wholegrain pigmented rice varieties were screened for their polyphenol content and antioxidant activity, of which, Yunlu29 (red), Purple (purple) and Reiziq (brown) had the highest values. The selected varieties were then subjected to in-vitro investigation to determine the effect of rice-derived PE on adipocyte differentiation. Lipid accumulation and peroxisome proliferator-activated receptor gamma (PPARγ) expression were quantified by oil red O staining and RT-PCR respectively. PE from Yunlu29 (red) and Purple rice varieties significantly reduced (p < 0.001) lipid accumulation by 53% and 56% respectively and PPARγ expression in adipocytes by 61.2% and 35.6% respectively. PE from Reiziq (brown), did not inhibit lipid accumulation in adipocytes however, did reduce PPARγ expression (p < 0.001).

U2 - 10.1016/j.jcs.2018.04.011

DO - 10.1016/j.jcs.2018.04.011

M3 - Article

VL - 81

SP - 140

EP - 146

JO - Journal of Cereal Science

JF - Journal of Cereal Science

SN - 0733-5210

ER -