Possibility of potential VWD misdiagnosis or misclassification using LIA technology and due to presence of rheumatoid factor

E J Favaloro, M Aboud, C Arthur

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

von Willebrand's disease (VWD) is now recognised to be the most common inherited bleeding disorder and is due to defects and/or deficiencies in von Willebrand factor (VWF). The latex immuno-assay (LIA) procedure has become a popular VWF:Ag detection methodology because of the ability to automate testing. In this report, we present findings which urge caution when normal LIA results are obtained co-incident to striking clinical findings strongly suggestive of VWD, or previous laboratory findings consistent with VWD. As illustrated by a relevant case study, normal LIA results may lead to an "incorrect diagnosis" of "not VWD" or to a potential subtype misdiagnosis, should they be accepted without cross-confirmation using alternative VWF methodologies.

Original languageEnglish
Pages (from-to)53-6
Number of pages4
JournalAmerican Journal of Hematology
Volume66
Issue number1
DOIs
Publication statusPublished - Jan 2001

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