TY - JOUR
T1 - Possible modes of action of the artemisinin-type compounds
AU - Olliaro, Piero L.
AU - Haynes, Richard K.
AU - Meunier, Bernard
AU - Yuthavong, Yongyuth
PY - 2001
Y1 - 2001
N2 - Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.
AB - Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.
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U2 - 10.1016/S1471-4922(00)01838-9
DO - 10.1016/S1471-4922(00)01838-9
M3 - Article
C2 - 11286794
AN - SCOPUS:0035005885
SN - 1471-4922
VL - 17
SP - 122
EP - 126
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 3
ER -
