TY - JOUR
T1 - Possible relationship between poor skin disorders prognosis and serum zinc level
T2 - A narrative review
AU - Abadie, Mohammed Al
AU - Sharara, Zinah
AU - Abadie, Miriam Al
AU - Ball, Patrick A.
AU - Morrissey, Hana
N1 - Funding Information:
This work was supported in part by the Brazilian agency, CNPq, National Council of Scientific and Technological Development, through grant 522413/96-0.
Publisher Copyright:
©Copyright: the Author(s), 2022.
PY - 2022
Y1 - 2022
N2 - Zinc is a trace nutrient essential for the normal growth and development of human body. The main aim was to evaluate the significant association between measured zinc status in relation to different skin disorders and their severity. PubMed®, Google® Scholar™ and Cochrane© Reviews databases were searched for studies from January 2017 to June 2021, using the terms; zinc serum levels, zinc plasma levels and different dermatosis in the review, only human studies in English language were reviewed and the studies designs were controlled, cross sectional, observational and analytic types. A total of forty-eight research studies were included in this review. All studies have evaluated serum zinc in skin diseases including psoriasis, atopic dermatitis, pityriasis alba, androgenetic alopecia areata, telogen effluvium, vitiligo, melasma, acne, seborrheic dermatitis and hidradenitis suppuritiva. It was found that 33 studies had validated statistically significant differences in serum zinc levels between patients and controls. There is a predominance of low serum zinc levels in all the dermatoses reviewed. The clinical significance of this finding highlights the possible value, and need to investigate, the use of zinc supplementation as an adjuvant therapy in the management of chronic inflammatory and autoimmune skin diseases proven to manifest altered zinc levels.
AB - Zinc is a trace nutrient essential for the normal growth and development of human body. The main aim was to evaluate the significant association between measured zinc status in relation to different skin disorders and their severity. PubMed®, Google® Scholar™ and Cochrane© Reviews databases were searched for studies from January 2017 to June 2021, using the terms; zinc serum levels, zinc plasma levels and different dermatosis in the review, only human studies in English language were reviewed and the studies designs were controlled, cross sectional, observational and analytic types. A total of forty-eight research studies were included in this review. All studies have evaluated serum zinc in skin diseases including psoriasis, atopic dermatitis, pityriasis alba, androgenetic alopecia areata, telogen effluvium, vitiligo, melasma, acne, seborrheic dermatitis and hidradenitis suppuritiva. It was found that 33 studies had validated statistically significant differences in serum zinc levels between patients and controls. There is a predominance of low serum zinc levels in all the dermatoses reviewed. The clinical significance of this finding highlights the possible value, and need to investigate, the use of zinc supplementation as an adjuvant therapy in the management of chronic inflammatory and autoimmune skin diseases proven to manifest altered zinc levels.
KW - atopic dermatitis
KW - autoimmune
KW - chronic inflammation
KW - dermatosis
KW - Serum Zinc
KW - Zinc supplementation
UR - http://www.scopus.com/inward/record.url?scp=85143206777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85143206777&partnerID=8YFLogxK
U2 - 10.4081/dr.2022.9512
DO - 10.4081/dr.2022.9512
M3 - Review article
C2 - 36483222
AN - SCOPUS:85143206777
SN - 2036-7392
VL - 14
JO - Dermatology Reports
JF - Dermatology Reports
IS - 4
M1 - 9512
ER -