TY - JOUR
T1 - Potential role of phenolic extracts of mentha in managing oxidative stress and alzheimer’s disease
AU - Hanafy, Doaa
AU - Burrows, Geoffrey E.
AU - Prenzler, Paul D.
AU - Hill, Rodney A.
PY - 2020/7/17
Y1 - 2020/7/17
N2 - With an increase in the longevity and thus the proportion of the elderly, especially in developed nations, there is a rise in pathological conditions that accompany ageing, such as neurodegenerative disorders. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive and memory decline. The pathophysiology of the disease is poorly understood, with several factors contributing to its development, such as oxidative stress, neuroinflammation, cholinergic neuronal apoptotic death, and the accumulation of abnormal proteins in the brain. Current medications are only palliative and cannot stop or reverse the progression of the disease. Recent clinical trials of synthetic compounds for the treatment of AD have failed because of their adverse effects or lack of efficacy. Thus, there is impetus behind the search for drugs from natural origins, in addition to the discovery of novel, conventional therapeutics. Mints have been used traditionally for conditions relevant to the central nervous system. Recent studies showed that mint extracts and/or their phenolic constituents have a neuroprotective potential and can target multiple events of AD. In this review, we provide evidence of the potential role of mint extracts and their derivatives as possible sources of treatments in managing AD. Some of the molecular pathways implicated in the development of AD are reviewed, with focus on apoptosis and some redox pathways, pointing to mechanisms that may be modulated for the treatment of AD, and the need for future research invoking knowledge of these pathways is highlighted.
AB - With an increase in the longevity and thus the proportion of the elderly, especially in developed nations, there is a rise in pathological conditions that accompany ageing, such as neurodegenerative disorders. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive and memory decline. The pathophysiology of the disease is poorly understood, with several factors contributing to its development, such as oxidative stress, neuroinflammation, cholinergic neuronal apoptotic death, and the accumulation of abnormal proteins in the brain. Current medications are only palliative and cannot stop or reverse the progression of the disease. Recent clinical trials of synthetic compounds for the treatment of AD have failed because of their adverse effects or lack of efficacy. Thus, there is impetus behind the search for drugs from natural origins, in addition to the discovery of novel, conventional therapeutics. Mints have been used traditionally for conditions relevant to the central nervous system. Recent studies showed that mint extracts and/or their phenolic constituents have a neuroprotective potential and can target multiple events of AD. In this review, we provide evidence of the potential role of mint extracts and their derivatives as possible sources of treatments in managing AD. Some of the molecular pathways implicated in the development of AD are reviewed, with focus on apoptosis and some redox pathways, pointing to mechanisms that may be modulated for the treatment of AD, and the need for future research invoking knowledge of these pathways is highlighted.
KW - Antioxidant
KW - Apoptosis
KW - Central nervous system
KW - Heme oxygenase
KW - Mint
KW - Neurodegeneration
KW - Neuroprotection
KW - Peroxiredoxin
KW - Thioredoxin
UR - http://www.scopus.com/inward/record.url?scp=85090737496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090737496&partnerID=8YFLogxK
U2 - 10.3390/antiox9070631
DO - 10.3390/antiox9070631
M3 - Review article
C2 - 32709074
AN - SCOPUS:85090737496
SN - 2076-3921
VL - 9
SP - 1
EP - 26
JO - Antioxidants
JF - Antioxidants
IS - 7
M1 - 631
ER -