Pre-analytical variables in coagulation testing associated with diagnostic errors in hemostasis

Emmanuel J. Favaloro, M. Dorothy, Giuseppe Lippi

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)


The use of modern laboratory instrumentation with high levels of test reliability and appropriate quality assurance measures will lead to very few analytical errors within hemostasis testing. Nevertheless, incorrect or inappropriate test results are still reported, often due to events outside the control of the laboratories performing the tests. This is due primarily to pre-analytical events associated with sample collection and processing, as well as post-analytical events related to the reporting and interpretation of test results. This review focuses on the pre-analytical phase, highlighting contributory elements and providing suggestions on how problems can be minimized or prevented, thereby improving the likelihood that reported test results actually represent the true clinical status of the patient rather than that of an inappropriate sample. This review should be of value to both laboratory personnel and clinicians because an appreciation of these issues will enable the optimal clinical management of patients.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalLaboratory Medicine
Issue number2
Publication statusPublished - Feb 2012


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