Preparation, evaluation and characterization of Rutin–Chitooligosaccharide complex

Ruge Cao, Qiuchen Ma, Yu Fu, Zhongkai Zhou, Xiaoyu Zhao

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Rutin possesses a wide range of application prospects with various bioactivities. However, its bitter and water-insoluble properties restrict its application in the field of functional foods. A new complex of rutin and chitooligosaccharide (Rutin-COS) was prepared via spray-drying method (100 °C, 1 L/h) and freeze-drying method (−80 °C, 24 h), respectively. The water solubility, bitterness, antioxidant and antibacterial activities of Rutin-COS were evaluated, and the complexation of Rutin-COS was characterized by SEM, 1H-NMR and ROESY. Compared to freeze-drying method, spray-drying method was more effective for preparing stable Rutin-COS complex. The spray-dried Rutin-COS showed increased water solubility, weakened bitterness, enhanced antioxidant and antibacterial activity compared to rutin. The Rutin-COS complex was demonstrated to be formed through hydrogen bonds between the A, B rings of rutin and COS.
    Original languageEnglish
    Pages (from-to)328-333
    Number of pages6
    JournalPlant Foods for Human Nutrition
    Early online date06 Jun 2019
    Publication statusPublished - 2019


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