Preparation of gama-aminobutyric acid-enriched rice bran and its modulation on gut microbiota and cognitive function of rats in high-fat diet

Wenting Shang, Xu Si, Yibo Li, Christopher Blanchard, Zhong Kai Zhou

Research output: Other contribution to conferenceAbstract

Abstract

In this study, gama-aminobutyric acid (GABA) in rice bran was promoted to be 8 times higher than its original one via anaerobic incubation. The GABA enriched rice bran (ERB) demonstrated a significantly increased anti-oxidant capacity following the incubation. The consumption of high-fat diet (HFD) with ERB was found to stimulate butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp. and associated synthesizing enzymes. This altered short-chain fatty acids distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by down-regulating orexigenic factors. Delightedly, the current study found GABA supplement delivered by rice bran significantly promoted hippocampal sulfatides synthesis, and reversed the HFD-induced sulfatides deficiency and oxidative-triggered mild cognitive impairment. Elevated GABA concentration in the hippocampus and the activation of GABA B-type receptors might be the primary contributors. This study highlights the potential of GABA enriched rice bran as a novel dietary supplement for benefiting the attenuation of chronic diseases.
Original languageEnglish
Pages35
Number of pages1
Publication statusPublished - 12 Sep 2018
Event68th Australasian Grain Science Conference - Charles Sturt University, Wagga Wagga, Australia
Duration: 10 Sep 201813 Sep 2018
https://www.ausgrainscience.org.au/wp-content/uploads/Conference2018/Booklet-2018.pdf (Conference booklet)

Conference

Conference68th Australasian Grain Science Conference
Abbreviated titleGrain Science Transforming our Future
CountryAustralia
CityWagga Wagga
Period10/09/1813/09/18
Internet address

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    Shang, W., Si, X., Li, Y., Blanchard, C., & Zhou, Z. K. (2018). Preparation of gama-aminobutyric acid-enriched rice bran and its modulation on gut microbiota and cognitive function of rats in high-fat diet. 35. Abstract from 68th Australasian Grain Science Conference, Wagga Wagga, Australia.