Abstract
In this study, gama-aminobutyric acid (GABA) in rice bran was promoted to be 8 times higher than its original one via anaerobic incubation. The GABA enriched rice bran (ERB) demonstrated a significantly increased anti-oxidant capacity following the incubation. The consumption of high-fat diet (HFD) with ERB was found to stimulate butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp. and associated synthesizing enzymes. This altered short-chain fatty acids distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by down-regulating orexigenic factors. Delightedly, the current study found GABA supplement delivered by rice bran significantly promoted hippocampal sulfatides synthesis, and reversed the HFD-induced sulfatides deficiency and oxidative-triggered mild cognitive impairment. Elevated GABA concentration in the hippocampus and the activation of GABA B-type receptors might be the primary contributors. This study highlights the potential of GABA enriched rice bran as a novel dietary supplement for benefiting the attenuation of chronic diseases.
Original language | English |
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Pages | 35 |
Number of pages | 1 |
Publication status | Published - 12 Sept 2018 |
Event | 68th Australasian Grain Science Conference - Charles Sturt University, Wagga Wagga, Australia Duration: 10 Sept 2018 → 13 Sept 2018 https://www.ausgrainscience.org.au/wp-content/uploads/Conference2018/Booklet-2018.pdf (Conference booklet) |
Conference
Conference | 68th Australasian Grain Science Conference |
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Abbreviated title | Grain Science Transforming our Future |
Country/Territory | Australia |
City | Wagga Wagga |
Period | 10/09/18 → 13/09/18 |
Internet address |