Preparation of molecularly imprinted polymers for the selective recognition of the bioactive polyphenol, (E)-resveratrol

Lachlan Schwarz, Basil Danylec, Simon J Harris, Reinhard I. Boysen, Milton T. W. Hearn

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

(E)-Resveratrol imprinted polymers have been rationally designed with the aid of molecular modelling and NMR spectroscopic titration techniques to determine the optimal ratio of the template to functional monomer for polymer formation. Based on this approach, (E)-resveratrol imprinted polymers were prepared via non-covalent self-assembly with the functional monomer 4-vinylpyridine (4VP) in a 1:3 molar ratio. Polymerisation in the presence of a cross-linker resulted in rigid block copolymers that had selective capacities towards (E)-resveratrol (e.g. 14 μmol/g) when compared to the non-imprinted reference polymer. The selectivity of these MIPs was also examined using several structurally related polyphenolic compounds to determine the influence of polyphenolic hydroxyl number and position on binding and molecular recognition.
Original languageEnglish
Pages (from-to)2189-2195
Number of pages7
JournalJournal of Chromatography
Volume1218
Issue number16
DOIs
Publication statusPublished - 2011

Fingerprint Dive into the research topics of 'Preparation of molecularly imprinted polymers for the selective recognition of the bioactive polyphenol, (E)-resveratrol'. Together they form a unique fingerprint.

  • Cite this