Prevalence and correlations of hepatorenal functions in diabetes and cardiovascular disease among stratified adults

Ezekiel Uba Nwose, Joshua Obianke, Ross Stuart Richards, Phillip Tederera Bwitit, Eunice Obiajuru Igumbor

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The vulnerability of older adults to diabetes and cardiovascular complications is a global concern. Hepatorenal pathophysiology is implicated in these complications, but has yet to be clearly established, especially from rural low-mid income countries. This study investigates differences in prevalence of diabetes in aging groups and correlations of age with hepatorenal variables. METHODS: 203 participants of both sexes above the age of 18 years underwent anthropometric measurements at Catholic Hospital, Abbi, Nigeria. Questionnaires collected demographic information and medical history. Urinalysis as well as routine liver and renal function tests were performed. Data analysis included determination of levels of hepatorenal abnormalities and prevalence of diseases in age groups. Percentage of disease subpopulations made up by each age-group was also determined as well as Pearson's correlation coefficient between age and hepatorenal variables, and comparison of average age and hepatorenal variables in disease subgroups. RESULTS: Percentage hepatorenal abnormalities are not significantly different between age-groups. There is no significant difference in percentage level of disease between groups, but in age-groups constituting disease sub-populations (p<0.00001). The apparently healthy subpopulation comprises of younger adults compared to older adults constituting diabetes and hypertension (p < 0…). Age shows moderate correlation with renal function parameters, especially urea and chloride (r = 0.42), but relatively insignificant with liver function variables. CONCLUSION: This report affirms that diabetes cardiovascular co-morbidity comes with aging.  It also indicates that renal pathophysiology may be more associated, than liver, functions in the vulnerability of adults.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalActa bio-medica : Atenei Parmensis
Volume90
Issue number1
DOIs
Publication statusPublished - 22 Jan 2019

Fingerprint

Cardiovascular Diseases
Age Groups
Kidney
Urinalysis
Liver
Liver Function Tests
Diabetes Complications
Nigeria
Urea
Chlorides
Young Adult
Demography
Hypertension
Morbidity
Population

Cite this

@article{6ca790c2336b41ee90e8c764f1a886e8,
title = "Prevalence and correlations of hepatorenal functions in diabetes and cardiovascular disease among stratified adults",
abstract = "BACKGROUND: The vulnerability of older adults to diabetes and cardiovascular complications is a global concern. Hepatorenal pathophysiology is implicated in these complications, but has yet to be clearly established, especially from rural low-mid income countries. This study investigates differences in prevalence of diabetes in aging groups and correlations of age with hepatorenal variables. METHODS: 203 participants of both sexes above the age of 18 years underwent anthropometric measurements at Catholic Hospital, Abbi, Nigeria. Questionnaires collected demographic information and medical history. Urinalysis as well as routine liver and renal function tests were performed. Data analysis included determination of levels of hepatorenal abnormalities and prevalence of diseases in age groups. Percentage of disease subpopulations made up by each age-group was also determined as well as Pearson's correlation coefficient between age and hepatorenal variables, and comparison of average age and hepatorenal variables in disease subgroups. RESULTS: Percentage hepatorenal abnormalities are not significantly different between age-groups. There is no significant difference in percentage level of disease between groups, but in age-groups constituting disease sub-populations (p<0.00001). The apparently healthy subpopulation comprises of younger adults compared to older adults constituting diabetes and hypertension (p < 0…). Age shows moderate correlation with renal function parameters, especially urea and chloride (r = 0.42), but relatively insignificant with liver function variables. CONCLUSION: This report affirms that diabetes cardiovascular co-morbidity comes with aging.  It also indicates that renal pathophysiology may be more associated, than liver, functions in the vulnerability of adults.",
author = "Nwose, {Ezekiel Uba} and Joshua Obianke and Richards, {Ross Stuart} and Bwitit, {Phillip Tederera} and Igumbor, {Eunice Obiajuru}",
year = "2019",
month = "1",
day = "22",
doi = "10.23750/abm.v90i1.6576",
language = "English",
volume = "90",
pages = "97--103",
journal = "Acta Biomedica de l'Ateneo Parmense",
issn = "0392-4203",
publisher = "L'Ateneo Parmense",
number = "1",

}

Prevalence and correlations of hepatorenal functions in diabetes and cardiovascular disease among stratified adults. / Nwose, Ezekiel Uba; Obianke, Joshua; Richards, Ross Stuart; Bwitit, Phillip Tederera; Igumbor, Eunice Obiajuru.

In: Acta bio-medica : Atenei Parmensis, Vol. 90, No. 1, 22.01.2019, p. 97-103.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence and correlations of hepatorenal functions in diabetes and cardiovascular disease among stratified adults

AU - Nwose, Ezekiel Uba

AU - Obianke, Joshua

AU - Richards, Ross Stuart

AU - Bwitit, Phillip Tederera

AU - Igumbor, Eunice Obiajuru

PY - 2019/1/22

Y1 - 2019/1/22

N2 - BACKGROUND: The vulnerability of older adults to diabetes and cardiovascular complications is a global concern. Hepatorenal pathophysiology is implicated in these complications, but has yet to be clearly established, especially from rural low-mid income countries. This study investigates differences in prevalence of diabetes in aging groups and correlations of age with hepatorenal variables. METHODS: 203 participants of both sexes above the age of 18 years underwent anthropometric measurements at Catholic Hospital, Abbi, Nigeria. Questionnaires collected demographic information and medical history. Urinalysis as well as routine liver and renal function tests were performed. Data analysis included determination of levels of hepatorenal abnormalities and prevalence of diseases in age groups. Percentage of disease subpopulations made up by each age-group was also determined as well as Pearson's correlation coefficient between age and hepatorenal variables, and comparison of average age and hepatorenal variables in disease subgroups. RESULTS: Percentage hepatorenal abnormalities are not significantly different between age-groups. There is no significant difference in percentage level of disease between groups, but in age-groups constituting disease sub-populations (p<0.00001). The apparently healthy subpopulation comprises of younger adults compared to older adults constituting diabetes and hypertension (p < 0…). Age shows moderate correlation with renal function parameters, especially urea and chloride (r = 0.42), but relatively insignificant with liver function variables. CONCLUSION: This report affirms that diabetes cardiovascular co-morbidity comes with aging.  It also indicates that renal pathophysiology may be more associated, than liver, functions in the vulnerability of adults.

AB - BACKGROUND: The vulnerability of older adults to diabetes and cardiovascular complications is a global concern. Hepatorenal pathophysiology is implicated in these complications, but has yet to be clearly established, especially from rural low-mid income countries. This study investigates differences in prevalence of diabetes in aging groups and correlations of age with hepatorenal variables. METHODS: 203 participants of both sexes above the age of 18 years underwent anthropometric measurements at Catholic Hospital, Abbi, Nigeria. Questionnaires collected demographic information and medical history. Urinalysis as well as routine liver and renal function tests were performed. Data analysis included determination of levels of hepatorenal abnormalities and prevalence of diseases in age groups. Percentage of disease subpopulations made up by each age-group was also determined as well as Pearson's correlation coefficient between age and hepatorenal variables, and comparison of average age and hepatorenal variables in disease subgroups. RESULTS: Percentage hepatorenal abnormalities are not significantly different between age-groups. There is no significant difference in percentage level of disease between groups, but in age-groups constituting disease sub-populations (p<0.00001). The apparently healthy subpopulation comprises of younger adults compared to older adults constituting diabetes and hypertension (p < 0…). Age shows moderate correlation with renal function parameters, especially urea and chloride (r = 0.42), but relatively insignificant with liver function variables. CONCLUSION: This report affirms that diabetes cardiovascular co-morbidity comes with aging.  It also indicates that renal pathophysiology may be more associated, than liver, functions in the vulnerability of adults.

UR - http://www.scopus.com/inward/record.url?scp=85063259458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063259458&partnerID=8YFLogxK

U2 - 10.23750/abm.v90i1.6576

DO - 10.23750/abm.v90i1.6576

M3 - Article

VL - 90

SP - 97

EP - 103

JO - Acta Biomedica de l'Ateneo Parmense

JF - Acta Biomedica de l'Ateneo Parmense

SN - 0392-4203

IS - 1

ER -