Protein complexes including PGRMC1 and actin-associated proteins are disrupted by AG-205

Sarah Teakel, Marina Ludescher, Bashar Thejer, Gereon Poschmann, Jade Forwood, Hans Neubauer, Michael A. Cahill

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in fertility, neuroprotection, steroidogenesis, membrane trafficking and in cancer cell biology. PGRMC1 represents a likely key regulator of cell metabolism and proliferation, as well as a potential target for anti-cancer therapies. To further understand the functions of PGRMC1 and the mechanism of the small molecule inhibitor of PGRMC1, AG-205, proteins differentially bound to PGRMC1 were identified following AG-205 treatment of MIA PaCa-2 cells. Our results suggest that AG-205 influences PGRMC1 interactions with the actin cytoskeleton. The binding of two PGRMC1-associated proteins that support this, RACK1 and alpha-Actinin-1, was reduced following AG-205 treatment. The biology associated with PGRMC1 binding partners identified here merits further investigation.
Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
Early online date21 Jan 2020
Publication statusPublished - 26 Mar 2020


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