Cross-linking in combination with mass spectrometry can be used as a tool for structural modeling of protein complexes and multidomain proteins. Although cross-links represent only weak structural constraints, the combination of a limited set of experimental cross-links with molecular docking/modeling is often sufficient to determine the structure of a protein complex or multidomain protein at low resolution.
|Title of host publication||Structural proteomics|
|Subtitle of host publication||high-throughput methods|
|Place of Publication||Totowa, N.J.|
|Number of pages||16|
|Publication status||Published - 2008|