Proteomic expression profiling of breast cancer

Hans Neubauer, Tanja Fehm, Christina Schütz, Runa Speer, Erich Solomayer, Andre Schrattenholz, Michael Cahill, Raffael Kurek

Research output: Book chapter/Published conference paperChapter

6 Citations (Scopus)

Abstract

Breast cancer is one of the most common cancers observed in women in industrialized Western countries. The development of novel diagnostic methods and the application of modern systemic therapies have significantly optimized early detection and therapy of breast cancer. However, many patients are currently overtreated. Traditionally, tumours have been categorized on the basis of histopathological criteria. However, staining pattern and intensity of cancer cells are not sufficient to reflect the molecular events driving tumour development and progression. Therefore, new genomic, transcriptomic and proteomic techniques are applied to clinical samples aiming to identify new targets for a therapy tailored for an individual patient. After an introduction to common genomic and transcriptomic profiling technologies and their relevance for clinical use, we will focus on analytical and preanalytical applications for the identification of new therapeutic targets by protein profiling, with a special emphasis on two-dimensional gel-technologies (2D-PAGE), particularly as they apply to the study of breast cancer.
Original languageEnglish
Title of host publicationTargeted Therapies in Cancer
EditorsManfred Dietel
Place of PublicationBerlin, Germany
PublisherSpringer
Pages89-120
Number of pages32
Volume176
Edition9
ISBN (Print)9783540460909
DOIs
Publication statusPublished - 2007

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Neubauer, H., Fehm, T., Schütz, C., Speer, R., Solomayer, E., Schrattenholz, A., Cahill, M., & Kurek, R. (2007). Proteomic expression profiling of breast cancer. In M. Dietel (Ed.), Targeted Therapies in Cancer (9 ed., Vol. 176, pp. 89-120). Springer. https://doi.org/10.1007/978-3-540-46091-6_9