Pulse width modulation electro-acupuncture on cardiovascular remodeling and plasma nitric oxide in spontaneously hypertensive rats

Xuan Xiong, Chao You, Qiu-Chao Feng, Ting Yin, Zhong-Ben Chen, Patrick Ball, Lexin Wang

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Abstract

This study was designed to investigate the effect of pulse width modulation electro-acupuncture(PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensiverats (SHR). Thirty-four male SHR were randomly divided into control, captopril, and twoPWM-EA groups, which were treated with 350 Hz (SHR-350Hz) and whole audio bandwithelectro-acupuncture (SHR-WAB group) respectively, on the ST 36 point located on the outsideof the hind leg. Systolic blood pressure (BP), plasma and myocardial NO were measured.Histological studies were also performed on the aortic wall and the left ventricle. The BP inthe SHR-350Hz, SHR-WAB and the captopril groups was lower than in the control groupfollowing the treatment (P50.05). The average aortic media wall thickness in the twoelectro-acupuncture groups was less than in the control group (P50.05). The left ventricle/heart weight ratio in the captopril and SHR-350Hz groups was less than in the control group(P50.01), but was similar between the SHR-WAB and the control group (P40.05). Theplasma and myocardium NO levels were elevated in the captopril and the SHR-350Hz group(P50.05 and 0.01, respectively). The plasma level of NO in the SHR-WAB group was alsohigher than in the control group (P50.05). We concluded that pulse width modulationelectro-acupuncture on the ST 36 point prevents the progression of hypertension and diminishesthe cardiovascular remodeling in SHR. It also elevates plasma and cardiac NO in this animalmodel.
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEvidence-Based Complementary and Alternative Medicine
Volume2011
Issue number812160 (Article ID)
Early online date2010
DOIs
Publication statusPublished - 2011

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