TY - JOUR
T1 - Quality standards for sample processing, transportation, and storage in hemostasis testing
AU - Adcock Funk, Dorothy M
AU - Lippi, Giuseppe
AU - Favaloro, Emmanuel J
N1 - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
PY - 2012/9
Y1 - 2012/9
N2 - Samples for hemostasis testing drawn into sodium citrate anticoagulant are vulnerable to the effects of preanalytical variables associated with sample processing, transportation, and storage. These variables include the temperature at which samples are transported and stored; the stability of the samples once processed; whether maintained at room temperature, refrigerated, or frozen; methods of centrifugation; as well as the potential impact of using an automated line. Acknowledgment of these variables, as well as understanding their potential impact on assay results, is imperative to the reporting of high quality and accurate results. This article discusses the preanalytical issues associated with sample processing, transportation, and storage and also presents the ideal conditions for sample handling.
AB - Samples for hemostasis testing drawn into sodium citrate anticoagulant are vulnerable to the effects of preanalytical variables associated with sample processing, transportation, and storage. These variables include the temperature at which samples are transported and stored; the stability of the samples once processed; whether maintained at room temperature, refrigerated, or frozen; methods of centrifugation; as well as the potential impact of using an automated line. Acknowledgment of these variables, as well as understanding their potential impact on assay results, is imperative to the reporting of high quality and accurate results. This article discusses the preanalytical issues associated with sample processing, transportation, and storage and also presents the ideal conditions for sample handling.
KW - Blood Coagulation Tests/methods
KW - Blood Specimen Collection/methods
KW - Centrifugation/standards
KW - Hemostasis
KW - Humans
KW - Prothrombin Time/standards
U2 - 10.1055/s-0032-1319768
DO - 10.1055/s-0032-1319768
M3 - Review article
C2 - 22706973
SN - 0094-6176
VL - 38
SP - 576
EP - 585
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
IS - 6
ER -