Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins; Waqas Amin Gill; Rosemarie Kringel; Guankui Wang; Jamie Hass; Suresh Acharya; Jungrae Park; In Tak Jeon; Boo Hyun An; Ji Sung Lee; Jong Eun Ryu; Rod Hill; David McIlroy; Young Keun Kim; Daniel S. Choi

doi:10.1088/1361-6528/28/3/03LT01

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins, Waqas Amin Gill, Rosemarie Kringel, Guankui Wang, Jamie Hass, Suresh Acharya, Jungrae Park, In Tak Jeon, Boo Hyun An, Ji Sung Lee, Jong Eun Ryu, Rod Hill, David McIlroy, Young Keun Kim, Daniel S. Choi

Research output: Contribution to journal › Letter › peer-review

12 Citations (Scopus)

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

Original language	English
Article number	03LT01
Pages (from-to)	1-9
Number of pages	9
Journal	Nanotechnology
Volume	28
Issue number	3
Early online date	14 Dec 2016
DOIs	https://doi.org/10.1088/1361-6528/28/3/03LT01
Publication status	Published - Jan 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1088/1361-6528/28/3/03LT01

Cite this

Hopkins, X., Gill, W. A., Kringel, R., Wang, G., Hass, J., Acharya, S., Park, J., Jeon, I. T., An, B. H., Lee, J. S., Ryu, J. E., Hill, R., McIlroy, D., Kim, Y. K., & Choi, D. S. (2017). Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. Nanotechnology, 28(3), 1-9. Article 03LT01. https://doi.org/10.1088/1361-6528/28/3/03LT01

@article{456e0e3b76424f058ec28fb2561847e4,

title = "Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires",

abstract = "We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.",

keywords = "RF-mediated thermotherapy, Magnetic core-shell nanowire, RF radiation, Cancer",

author = "Xiaoping Hopkins and Gill, {Waqas Amin} and Rosemarie Kringel and Guankui Wang and Jamie Hass and Suresh Acharya and Jungrae Park and Jeon, {In Tak} and An, {Boo Hyun} and Lee, {Ji Sung} and Ryu, {Jong Eun} and Rod Hill and David McIlroy and Kim, {Young Keun} and Choi, {Daniel S.}",

note = "Includes bibliographical references.",

year = "2017",

month = jan,

doi = "10.1088/1361-6528/28/3/03LT01",

language = "English",

volume = "28",

pages = "1--9",

journal = "Nanotechnology",

issn = "0957-4484",

publisher = "IOP Publishing Ltd.",

number = "3",

}

TY - JOUR

T1 - Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

AU - Hopkins, Xiaoping

AU - Gill, Waqas Amin

AU - Kringel, Rosemarie

AU - Wang, Guankui

AU - Hass, Jamie

AU - Acharya, Suresh

AU - Park, Jungrae

AU - Jeon, In Tak

AU - An, Boo Hyun

AU - Lee, Ji Sung

AU - Ryu, Jong Eun

AU - Hill, Rod

AU - McIlroy, David

AU - Kim, Young Keun

AU - Choi, Daniel S.

N1 - Includes bibliographical references.

PY - 2017/1

Y1 - 2017/1

N2 - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

AB - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

KW - RF-mediated thermotherapy

KW - Magnetic core-shell nanowire

KW - RF radiation

KW - Cancer

U2 - 10.1088/1361-6528/28/3/03LT01

DO - 10.1088/1361-6528/28/3/03LT01

M3 - Letter

C2 - 27966462

SN - 0957-4484

VL - 28

SP - 1

EP - 9

JO - Nanotechnology

JF - Nanotechnology

IS - 3

M1 - 03LT01

ER -

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this