Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins, Waqas Amin Gill, Rosemarie Kringel, Guankui Wang, Jamie Hass, Suresh Acharya, Jungrae Park, In Tak Jeon, Boo Hyun An, Ji Sung Lee, Jong Eun Ryu, Rod Hill, David McIlroy, Young Keun Kim, Daniel S. Choi

Research output: Contribution to journalLetter

5 Citations (Scopus)

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)–gold (Au) core–shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni–Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.
Original languageEnglish
Article number03LT01
Pages (from-to)1-9
Number of pages9
JournalNanotechnology
Volume28
Issue number3
Early online date14 Dec 2016
DOIs
Publication statusPublished - Jan 2017

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