Reactions of (RP)- and (SP)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with heteroatom nucleophiles; preparation of P-chiral binol phosphinates and related compounds

Tin Lok Au-Yeung, Ka Yee Chan, Wai Kuen Chan, Richard K. Haynes, Ian D. Williams, Lam Lung Yeung

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Abstract

Reaction of (RP)- and (SP)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with metallated phenol and BINOL alkoxides, thioalkoxides, amides and enolates leading with clean inversion at phosphorus to phosphinates, phosphinothiolates and phosphinoamidates, and the corresponding thionophosphorus compounds are described.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number3
DOIs
Publication statusPublished - 15 Jan 2001

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