Psittacine beak and feather disease (PBFD) remains one of the most common viral diseases of both wild and captive birds, even after over 20 years of research and many attempts to develop options for vaccination and treatment. Many different researchers have attempted unsuccessfully to grow the virus in cell culture and a vaccine has even been produced, but is not a commercial reality due to the difficulty of producing enough antigen. Recombinant protein technology is widely used to study the structure and function of many proteins and these recombinant proteins are also gaining favour as alternatives to attenuated or inactivated vaccines. We present here the production of a recombinant His-tagged Beak and Feather Disease Virus (BFDV) capsid fusion protein using a baculovirus expression system and subsequent evidence that this protein is morphologically and functionally similar to native virus particles.
|Title of host publication||AAVAC and UEPV Annual Conference|
|Place of Publication||Australia|
|Number of pages||4|
|Publication status||Published - 2006|
|Event||Association of Avian Veterinarians Australasian Chapter (AAVAC) and Unusual and Exotic Pet Veterinarians (UEPV), Combined Conference - Wellington, New Zealand, New Zealand|
Duration: 02 Sep 2006 → 06 Sep 2006
|Conference||Association of Avian Veterinarians Australasian Chapter (AAVAC) and Unusual and Exotic Pet Veterinarians (UEPV), Combined Conference|
|Period||02/09/06 → 06/09/06|
Shearer, PL., Bonne, N., Khalesi, B., Stewart, ME., Sharp, M., & Raidal, S. (2006). Recombinant BFDV capsid protein: the 'I can't believe it's not butter' of viruses. In G. Cross (Ed.), AAVAC and UEPV Annual Conference (pp. 187-190). AAVAC.