Reduced expression of APC and DCC gene protein in breast cancer

Tuen Mun Hospital Hong Kong K.Y.K. Ho; Wouter Kalle; Tuen Mun Hospital Hong Kong T.H.S. Lo; Tuen Mun Hospital Hong Kong W.Y. Lam; Tuen Mun Hospital Hong Kong C.M.C. Tang

doi:10.1046/j.1365-2559.1999.00725.x

Reduced expression of APC and DCC gene protein in breast cancer

Tuen Mun Hospital Hong Kong K.Y.K. Ho, Wouter Kalle, Tuen Mun Hospital Hong Kong T.H.S. Lo, Tuen Mun Hospital Hong Kong W.Y. Lam, Tuen Mun Hospital Hong Kong C.M.C. Tang

Dentistry and Medical Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

AimsTo investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in the development and progression of breast cancer using colorectal cancer as a control model.Methods and resultsThe reduced or loss of protein expression of the APC and DCC genes was studied in 27 surgical specimens of primary breast cancer using an immunohistochemical method. Reduced or lost expression was identified in 11 out of 27 samples (40.7%) for the APC gene and 15 out of 27 samples (55.6%) for the DCC gene. No statistically significant difference was observed between the reduced or lost protein expression and the histological grading of breast tumour for both the APC and the DCC gene.

Original language	English
Pages (from-to)	249-256
Number of pages	8
Journal	Histopathology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2559.1999.00725.x
Publication status	Published - 1999

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10.1046/j.1365-2559.1999.00725.x

Cite this

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title = "Reduced expression of APC and DCC gene protein in breast cancer",

abstract = "AimsTo investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in the development and progression of breast cancer using colorectal cancer as a control model.Methods and resultsThe reduced or loss of protein expression of the APC and DCC genes was studied in 27 surgical specimens of primary breast cancer using an immunohistochemical method. Reduced or lost expression was identified in 11 out of 27 samples (40.7%) for the APC gene and 15 out of 27 samples (55.6%) for the DCC gene. No statistically significant difference was observed between the reduced or lost protein expression and the histological grading of breast tumour for both the APC and the DCC gene.",

keywords = "APC gene, Breast neoplasm, DCC gene, Immunohistochemistry",

author = "{K.Y.K. Ho}, {Tuen Mun Hospital Hong Kong} and Wouter Kalle and {T.H.S. Lo}, {Tuen Mun Hospital Hong Kong} and {W.Y. Lam}, {Tuen Mun Hospital Hong Kong} and {C.M.C. Tang}, {Tuen Mun Hospital Hong Kong}",

note = "Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Histopathology. ISSNs: 0309-0167; ",

year = "1999",

doi = "10.1046/j.1365-2559.1999.00725.x",

language = "English",

volume = "35",

pages = "249--256",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Verlag f{\"u}r Wissenschaft und Forschung",

number = "3",

}

TY - JOUR

T1 - Reduced expression of APC and DCC gene protein in breast cancer

AU - K.Y.K. Ho, Tuen Mun Hospital Hong Kong

AU - Kalle, Wouter

AU - T.H.S. Lo, Tuen Mun Hospital Hong Kong

AU - W.Y. Lam, Tuen Mun Hospital Hong Kong

AU - C.M.C. Tang, Tuen Mun Hospital Hong Kong

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Histopathology. ISSNs: 0309-0167;

PY - 1999

Y1 - 1999

N2 - AimsTo investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in the development and progression of breast cancer using colorectal cancer as a control model.Methods and resultsThe reduced or loss of protein expression of the APC and DCC genes was studied in 27 surgical specimens of primary breast cancer using an immunohistochemical method. Reduced or lost expression was identified in 11 out of 27 samples (40.7%) for the APC gene and 15 out of 27 samples (55.6%) for the DCC gene. No statistically significant difference was observed between the reduced or lost protein expression and the histological grading of breast tumour for both the APC and the DCC gene.

AB - AimsTo investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in the development and progression of breast cancer using colorectal cancer as a control model.Methods and resultsThe reduced or loss of protein expression of the APC and DCC genes was studied in 27 surgical specimens of primary breast cancer using an immunohistochemical method. Reduced or lost expression was identified in 11 out of 27 samples (40.7%) for the APC gene and 15 out of 27 samples (55.6%) for the DCC gene. No statistically significant difference was observed between the reduced or lost protein expression and the histological grading of breast tumour for both the APC and the DCC gene.

KW - APC gene

KW - Breast neoplasm

KW - DCC gene

KW - Immunohistochemistry

U2 - 10.1046/j.1365-2559.1999.00725.x

DO - 10.1046/j.1365-2559.1999.00725.x

M3 - Article

SN - 0309-0167

VL - 35

SP - 249

EP - 256

JO - Histopathology

JF - Histopathology

IS - 3

ER -

Reduced expression of APC and DCC gene protein in breast cancer

Abstract

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