Reduced expression of APC and DCC gene protein in breast cancer

Tuen Mun Hospital Hong Kong K.Y.K. Ho, Wouter Kalle, Tuen Mun Hospital Hong Kong T.H.S. Lo, Tuen Mun Hospital Hong Kong W.Y. Lam, Tuen Mun Hospital Hong Kong C.M.C. Tang

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Abstract

AimsTo investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in the development and progression of breast cancer using colorectal cancer as a control model.Methods and resultsThe reduced or loss of protein expression of the APC and DCC genes was studied in 27 surgical specimens of primary breast cancer using an immunohistochemical method. Reduced or lost expression was identified in 11 out of 27 samples (40.7%) for the APC gene and 15 out of 27 samples (55.6%) for the DCC gene. No statistically significant difference was observed between the reduced or lost protein expression and the histological grading of breast tumour for both the APC and the DCC gene.
Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalHistopathology
Volume35
Issue number3
Publication statusPublished - 1999

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    K.Y.K. Ho, T. M. H. H. K., Kalle, W., T.H.S. Lo, T. M. H. H. K., W.Y. Lam, T. M. H. H. K., & C.M.C. Tang, T. M. H. H. K. (1999). Reduced expression of APC and DCC gene protein in breast cancer. Histopathology, 35(3), 249-256.