Reduced mania and depression in juvenile bipolar disorder associated with long-chain ω-3 polyunsaturated fatty acid supplementation

E. H. Clayton, T. L. Hanstock, S. J. Hirneth, C. J. Kable, M. L. Garg, P. L. Hazell

    Research output: Contribution to journalArticlepeer-review

    113 Citations (Scopus)

    Abstract

    Long-chain ω-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation may improve symptoms of depression in children and bipolar disorder (BD) in adults. No studies have examined the effectiveness of LCn-3PUFA supplementation in the treatment of mania and depression in juvenile BD (JBD) when given as an adjunct to standard pharmacological treatment. Eighteen children and adolescents with JBD received supplements containing 360mg per day eicosapentaenoic acid (EPA) and 1560mg per day docosahexaenoic acid (DHA) for 6 weeks in an open-label study. Intake and fasting red blood cell (RBC) LCn-3PUFA, mania, depression and global function were assessed before and after supplementation. RBC EPA and DHA were significantly higher following supplementation. Clinician ratings of mania and depression were significantly lower and global functioning significantly higher after supplementation. Parent ratings of internalizing and externalizing behaviours were also significantly lower following supplementation. A larger randomized controlled trial appears warranted in this participant population.

    Original languageEnglish
    Pages (from-to)1037-1040
    Number of pages4
    JournalEuropean Journal of Clinical Nutrition
    Volume63
    Issue number8
    DOIs
    Publication statusPublished - 22 Jan 2009

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