Major depressive disorder (MDD) is associated with a number of comorbidities including cardiovascular disease (CVD), with an increased risk of death after myocardial. The aim of this study was to investigate if parameters for ventricular repolarization variability and dynamics in ECG signals are different in MDD patients with/without suicidal ideation and healthy volunteers. Sixty-one ECG recordings (10 minutes) were acquired and analysed from control subjects (44 CONT), 20 MDD subjects with (MDDSI+) and 21 without suicidal ideation [SI] (MDDSI-) for a case-control analysis at a psychiatric clinic in the UAE. The Mini-International Neuropsychiatric Interview (MINI) made diagnoses of MDD and the subscale for was used to evaluate the patients' suicidal intensions [0 to 38]. The subscale for SI consists of 19 items, which was used to evaluate the patients' suicidal intensions [0 to 38]. Then heart rate-corrected QT interval (QTc), QT/RR slope, QT variability (QTV), Median T-wave amplitudes and T-wave variability were estimated. MDD patients with suicidal ideation displayed increased QT/RR slope and reduced QTV, which may reflect abnormal ventricular repolarization liability and lead to higher risk of cardiac arrhythmia and future cardiovascular diseases.
|Title of host publication||Computing in Cardiology 2016|
|Place of Publication||United States|
|Publisher||IEEE, Institute of Electrical and Electronics Engineers|
|Number of pages||4|
|Publication status||Published - 2016|
|Event||43rd Computing in Cardiology Conference, CinC 2016 - Marriot Hotel and Simon Fraser University, Vancouver, Canada|
Duration: 11 Sept 2016 → 14 Sept 2016
https://web.archive.org/web/20160908015049/http://www.cinc2016.org/ (Conference website)
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=7861973 (Conference proceedings - IEEE)
|Conference||43rd Computing in Cardiology Conference, CinC 2016|
|Period||11/09/16 → 14/09/16|
|Other||Computing in Cardiology (formerly Computers in Cardiology) is an international scientific conference that has been held annually since 1974. CinC provides a forum for scientists and professionals from the fields of medicine, physics, engineering and computer science to discuss their current research in topics pertaining to computing in clinical cardiology and cardiovascular physiology.|
Attendees present and learn about leading-edge work at the interface of clinical practice, engineering, and basic research during three days of plenary, parallel, and poster sessions.