Reduced QT variability and increased QT/RR slope in ECG signals of depressed patients with suicidal ideation

A. H. Khandoker, V. Luthra, Y. Abouallaban, M. A. Hasan, N Chowdhury, H. F. Jelinek

Research output: Book chapter/Published conference paperConference paper

Abstract

Major depressive disorder (MDD) is associated with a number of comorbidities including cardiovascular disease (CVD), with an increased risk of death after myocardial. The aim of this study was to investigate if parameters for ventricular repolarization variability and dynamics in ECG signals are different in MDD patients with/without suicidal ideation and healthy volunteers. Sixty-one ECG recordings (10 minutes) were acquired and analysed from control subjects (44 CONT), 20 MDD subjects with (MDDSI+) and 21 without suicidal ideation [SI] (MDDSI-) for a case-control analysis at a psychiatric clinic in the UAE. The Mini-International Neuropsychiatric Interview (MINI) made diagnoses of MDD and the subscale for was used to evaluate the patients' suicidal intensions [0 to 38]. The subscale for SI consists of 19 items, which was used to evaluate the patients' suicidal intensions [0 to 38]. Then heart rate-corrected QT interval (QTc), QT/RR slope, QT variability (QTV), Median T-wave amplitudes and T-wave variability were estimated. MDD patients with suicidal ideation displayed increased QT/RR slope and reduced QTV, which may reflect abnormal ventricular repolarization liability and lead to higher risk of cardiac arrhythmia and future cardiovascular diseases.
Original languageEnglish
Title of host publicationComputing in Cardiology 2016
Subtitle of host publicationVolume 43
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages393-396
Number of pages4
Volume43
ISBN (Electronic)9781509008957
ISBN (Print)9781509008964
Publication statusPublished - 2016
Event43rd Computing in Cardiology Conference, CinC 2016 - Marriot Hotel and Simon Fraser University, Vancouver, Canada
Duration: 11 Sep 201614 Sep 2016
https://web.archive.org/web/20170603121743/http://cinc2016.org (Conference website)
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=7861973 (Conference proceedings)

Conference

Conference43rd Computing in Cardiology Conference, CinC 2016
CountryCanada
CityVancouver
Period11/09/1614/09/16
OtherComputing in Cardiology provides an international forum for scientists and professionals from the fields of medicine, physics, engineering and computer science, and has been held annually since 1974.
Internet address

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    Khandoker, A. H., Luthra, V., Abouallaban, Y., Hasan, M. A., Chowdhury, N., & Jelinek, H. F. (2016). Reduced QT variability and increased QT/RR slope in ECG signals of depressed patients with suicidal ideation. In Computing in Cardiology 2016: Volume 43 (Vol. 43, pp. 393-396). [7868762] IEEE, Institute of Electrical and Electronics Engineers. https://ieeexplore.ieee.org/document/7868762