Regulatory squelching

M A Cahill, W H Ernst, R Janknecht, A Nordheim

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)


An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.

Original languageEnglish
Pages (from-to)105-8
Number of pages4
JournalFEBS Letters
Issue number2-3
Publication statusPublished - 16 May 1994


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