Regulatory squelching

M A Cahill; W H Ernst; R Janknecht; A Nordheim

doi:10.1016/0014-5793(94)00320-3

Regulatory squelching

M A Cahill, W H Ernst, R Janknecht, A Nordheim

Nursing, Paramedicine and Healthcare Sciences

Research output: Contribution to journal › Review article › peer-review

64 Citations (Scopus)

Abstract

An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.

Original language	English
Pages (from-to)	105-8
Number of pages	4
Journal	FEBS Letters
Volume	344
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-5793(94)00320-3
Publication status	Published - 16 May 1994

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10.1016/0014-5793(94)00320-3

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title = "Regulatory squelching",

abstract = "An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.",

keywords = "Animals, DNA, Gene Expression Regulation, Models, Genetic, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Journal Article, Review",

author = "Cahill, {M A} and Ernst, {W H} and R Janknecht and A Nordheim",

year = "1994",

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T1 - Regulatory squelching

AU - Cahill, M A

AU - Ernst, W H

AU - Janknecht, R

AU - Nordheim, A

PY - 1994/5/16

Y1 - 1994/5/16

N2 - An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.

AB - An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle-dependent and differentiation-specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be important than hitherto appreciated.

KW - Animals

KW - DNA

KW - Gene Expression Regulation

KW - Models, Genetic

KW - Promoter Regions, Genetic

KW - Transcription Factors

KW - Transcription, Genetic

KW - Journal Article

KW - Review

UR - http://www.ncbi.nlm.nih.gov/pubmed/8187867

U2 - 10.1016/0014-5793(94)00320-3

DO - 10.1016/0014-5793(94)00320-3

M3 - Review article

C2 - 8187867

SN - 0014-5793

VL - 344

SP - 105

EP - 108

JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -

Regulatory squelching

Abstract

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