Relations between plasma von Willebrand factor or endothelin-1 and restenosis following carotid artery stenting

Hua Yang, J.-X. Xu, X.-Z. Kong, Z.-G. Ren, Z.-Y. Xia, H.-Q. Qu, Lexin Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)
6 Downloads (Pure)

Abstract

Objective: This study was designed to investigate the relation between plasma von Willebrand factor (VWF) or endothelin-1 (ET-1) and post-carotid artery stenting (CAS) restenosis. Materials andMethods: Plasma levels of VWF and ET-1 were measured in 61 patients (36 males, mean age 64.4 ± 6.8 years) before and after CAS. The mean follow-up time was 13.8 ± 1.7 months (range, 6'63). In-stent restenosis was defined as a >10% narrowing of the vascular lumen with or without ischemic symptoms following CAS. Results: In-stent restenosis was identified in 14 (23%) patients, including 3 with >50% restenosis. In the restenosis group, mean VWF and ET-1 levels at 2 weeks, 1 and 6 months after CAS were higher than the baseline levels (p < 0.05 or p < 0.01). Mean levels of VWF and ET-1 in the restenosis group were higher than in the non-restenosis group within 6 months after CAS (p < 0.05 or p < 0.01). Conclusion: Persistent elevation in plasma VWF and ET-1 within the first 6 months of CAS was found in patients with in-stent restenosis.
Original languageEnglish
Pages (from-to)538-42
Number of pages5
JournalMedical Principles and Practice
Volume21
Issue number6
DOIs
Publication statusPublished - 2012

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