Relationship between adiponectin and testosterone in patients with type 2 diabetes

J. Bai, Y., Liu, G.-F., Niu, Li-Xin Bai, X.-Y Xu, G.-Z., Zhang, Lexin Wang

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Abstract

Introduction: This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes.Materials and methods: Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay, whereas adiponectin levels weredetermined by enzyme-linked immunosorbent assay (ELISA).Results:The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05,P = 0.167).Conclusions: We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics.
Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalBiochemia Medica
Volume25
Issue number1
Publication statusPublished - Feb 2011

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