Purpose: This study investigated the relationship between estimated oxygen consumption (VO2max) and handgrip strength (HGS) among healthy young Nigerian adults. Methods: This was a cross sectional study, which involved 400 volunteers (171 males; 229 females) aged between 18–40years. Participants’ HGS was assessed using a CAMRY EH-101 hand dynamometer while VO2max was estimated using a standard formula that includes measurement of resting heart rate. Demographic data was summarized using percentages, mean and standard deviation. Physical activity level of the participants was assessed using long form of the International Physical Activity Questionnaire. Independent t-test was used to compare the mean values of the variables between male and female participants. Pearson’s correlation was used to determine the strength of relationship between estimated VO2max and HGS, while multiple regression analysis was conducted to determine the predictors of estimated VO2max using HGS as well as body mass index (BMI), physical activity (PA) level, age and sex as co‐variates. Level of significance was set at p<0.05. Results: HGS, VO2max and PA level were significantly (p= 0.001) different between male and female participants. There was a significant moderate correlation between HGS and VO2max (r= 0.40, p= 0.001). The results of the regression analysis showed that HGS is not significant predictor of estimated VO2max; whereas, sex, BMI and PA level were significant predictors of estimated VO2max. Conclusion: Although HGS is moderately correlated with estimated VO2max, HGS may not be a relevant tool for predicting estimated VO2max in healthy young adults.